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The Asthma Bronchial Challenge Study

NCT03575663 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2019-04-25

No results posted yet for this study

Summary

This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate asthma.

Participants will undergo baseline evaluation including clinical history, spirometry, exhaled nitric oxide measurement (FeNO), phlebotomy (blood eosinophil count), and sampling of exhaled breath VOCs. Participants will be randomised to receive either an indirect bronchial challenge test using mannitol dry powder (MDP) or a sham bronchial challenge, followed by further sampling of breath VOCs. The study will consist of a consent visit and two assessment visits with participants allocated to receive one of the two challenges (MDP or sham) at each assessment. Data will be analysed to determine the effect of bronchial challenge upon exhaled breath VOC profiles.

Conditions

Interventions

DIAGNOSTIC_TEST

Indirect bronchial challenge

Mannitol dry powder inhalation

OTHER

Sham bronchial challenge

Mock dry powder inhalation

Sponsors & Collaborators

  • University of Manchester

    collaborator OTHER

  • Asthma UK Centre for Applied Research

    collaborator UNKNOWN

  • University of East Anglia

    lead OTHER

Principal Investigators

  • Adam M Peel, BSc · University of East Anglia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-25
Primary Completion
2019-02-19
Completion
2019-02-28

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03575663 on ClinicalTrials.gov