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Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma

NCT03568032 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 248

Last updated 2018-06-26

No results posted yet for this study

Summary

Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke. Currently, little is known about the incidence of radiation-associated carotid vasculopahty in the context of intensity-modulated radiation therapy (IMRT).

The aim of this study is to determine whether IMRT will increase the incidence of carotid vasculopathy in patients with nasopharyngeal carcinoma (NPC).

Conditions

  • Nasopharyngeal Carcinoma
  • Carotid Artery Diseases

Interventions

DIAGNOSTIC_TEST

Measurement of intima media thickness of carotid artery

IMT measurements were performed using ultrasound machine in the pre-radiation and the post-radiation group. IMT was assessed at the common carotid artery (CCA) and the internal carotid artery (ICA) of both the left and right side.

DIAGNOSTIC_TEST

Detection and measurement of carotid plaques

Detection and measurement of plaques within internal carotid artery and common carotid artery by ultrasound

DIAGNOSTIC_TEST

Carotid Color Flow Duplex Testing

Velocity measurement of carotid artery to determine carotid stenosis

DIAGNOSTIC_TEST

Montreal Cognitive Assessment

Cognitive assessment

OTHER

Medical history of cardiovascular risk factors and cardiovascular diseases

Cardiovascular risk factors include smoking, alcohol consumption, hypertension, diabetes mellitus, hypercholesterolemia, obesity. Cardiovascular diseases include ischemic stroke, ischemic coronary heart disease, TIA, etc.

Sponsors & Collaborators

  • Fudan University

    lead OTHER

Principal Investigators

  • Xiayun He, MD · Fudan University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2019-05-01
Completion
2019-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03568032 on ClinicalTrials.gov