TReatment of Irritable Bowel Syndrome With Diarrhoea Using Titrated ONdansetron Trial

Summary

A placebo controlled study to determine the efficacy and mode of action of ondansetron in the treatment of irritable bowel syndrome with diarrhoea.

Conditions

• IBS - Irritable Bowel Syndrome

Interventions

DRUG

Ondansetron

Ondansetron is a highly selective receptor antagonist (5-HT3RA)

Sponsors & Collaborators

• Barnsley Hospital NHS Foundation Trust

  collaborator OTHER

• Barts & The London NHS Trust

  collaborator OTHER

• County Durham and Darlington NHS Foundation Trust

  collaborator OTHER_GOV

• Flinders University

  collaborator OTHER

• The Leeds Teaching Hospitals NHS Trust

  collaborator OTHER

• London North West Healthcare NHS Trust

  collaborator OTHER

• NHS Lothian

  collaborator OTHER_GOV

• Queen Mary University of London

  collaborator OTHER

• Sandwell & West Birmingham Hospitals NHS Trust

  collaborator OTHER

• Sheffield Teaching Hospitals NHS Foundation Trust

  collaborator OTHER

• University College London Hospitals

  collaborator OTHER

• University Hospitals of North Midlands NHS Trust

  collaborator OTHER

• Manchester University NHS Foundation Trust

  collaborator OTHER_GOV

• University of Manchester

  collaborator OTHER

• National Institute for Health Research, United Kingdom

  collaborator OTHER_GOV

• University of Leeds

  lead OTHER

Principal Investigators

• Robin Spiller · University of Nottingham

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-03-29

Primary Completion

2020-08-03

Completion

2020-09-10

Countries

• United Kingdom

Study Locations