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Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis

NCT03539770 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2018-07-24

No results posted yet for this study

Summary

Adolescent Idiopathic Scoliosis (AIS) is a curvature of the spine that occurs in 1-2% of otherwise healthy children, and requires corrective surgery, posterior spinal fusion (PSF) in \~10% of cases. Some studies suggest that pulmonary function is reduced in AIS and that PSF improves pulmonary function. The lung is composed of a large number of branching airways that terminate in gas exchanging units called alveoli, and the number and structure of these alveoli are partially dependent upon lung volume and the forces to which they are exposed--two factors predicted to be altered in AIS. This study uses MRI imaging of inhaled helium to quantify alveolar structure in children with and without AIS before and one-year after PSF. The goals of the study are to determine if alveolar architecture or number are altered in AIS and whether PSF impacts these same measures.

Conditions

  • Scoliosis Idiopathic Adolescent

Interventions

PROCEDURE

Posterior spinal fusion

Surgical procedure that involves placement of spinal rods to correct spinal curvature

Sponsors & Collaborators

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Eligibility

Min Age
8 Years
Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-11-01
Primary Completion
2018-05-31
Completion
2018-05-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03539770 on ClinicalTrials.gov