Trial Outcomes & Findings for Behavioral Economic Analysis of Demand for Marijuana (NCT NCT03518567)
NCT ID: NCT03518567
Last Updated: 2024-02-12
Results Overview
The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.
COMPLETED
PHASE2
133 participants
Duration of the experimental session (i.e., 60 minutes)
2024-02-12
Participant Flow
Participant milestones
| Measure |
High THC Dose (6% THC)
Smoked marijuana cigarettes (High THC dose \[6% THC\])
|
|---|---|
|
Overall Study
STARTED
|
133
|
|
Overall Study
Completed Baseline
|
114
|
|
Overall Study
Completed Session 1
|
101
|
|
Overall Study
Completed Session 2
|
72
|
|
Overall Study
COMPLETED
|
72
|
|
Overall Study
NOT COMPLETED
|
61
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Behavioral Economic Analysis of Demand for Marijuana
Baseline characteristics by cohort
| Measure |
High THC Dose (6% THC)
n=114 Participants
Smoked marijuana cigarettes (High THC dose \[6% THC\])
Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose \[6% THC\])
|
|---|---|
|
Age, Continuous
|
26.6 years
STANDARD_DEVIATION 5.4 • n=99 Participants
|
|
Sex: Female, Male
Female
|
50 Participants
n=99 Participants
|
|
Sex: Female, Male
Male
|
64 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
20 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
94 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Asian
|
10 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Black or African American
|
19 Participants
n=99 Participants
|
|
Race (NIH/OMB)
White
|
72 Participants
n=99 Participants
|
|
Race (NIH/OMB)
More than one race
|
9 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
4 Participants
n=99 Participants
|
PRIMARY outcome
Timeframe: Duration of the experimental session (i.e., 60 minutes)Population: All participants who completed Session 1 (n=101), reported purchasing at least 1 hit from a cannabis joint at their randomly selected price-point on the Marijuana Purchase Task (n=90), and chose to smoke during the Session (n=86) were included in the analysis. Outcome corresponds to percentage of participants who smoked exactly what they said they would.
The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.
Outcome measures
| Measure |
High THC Dose (6% THC)
n=86 Participants
Smoked marijuana cigarettes (High THC dose \[6% THC\])
Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose \[6% THC\])
|
|---|---|
|
Validity of the Marijuana Purchase Task (MPT)
|
63 percentage of participants
|
SECONDARY outcome
Timeframe: The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hoursPopulation: All participants who completed Session 1 (n=101), reported purchasing at least 1 hit from a cannabis joint at their randomly selected price-point on the Marijuana Purchase Task (n=90), and chose to smoke during the Session (n=86) were included in the analysis.
Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire. Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score. Total craving score was used in analyses.
Outcome measures
| Measure |
High THC Dose (6% THC)
n=86 Participants
Smoked marijuana cigarettes (High THC dose \[6% THC\])
Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose \[6% THC\])
|
|---|---|
|
Change in Marijuana Craving Questionnaire (MCQ)
|
-0.75 units on the MCQ
Standard Deviation 1.09
|
SECONDARY outcome
Timeframe: Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.Population: Participants who completed Session 2 with usable smoking topography data.
Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The outcome measure is number of puffs.
Outcome measures
| Measure |
High THC Dose (6% THC)
n=67 Participants
Smoked marijuana cigarettes (High THC dose \[6% THC\])
Smoked marijuana cigarettes: High THC dose (6% THC): Smoked marijuana cigarettes (High THC dose \[6% THC\])
|
|---|---|
|
Marijuana Smoking Topography
|
29 puffs
Standard Deviation 13.7
|
Adverse Events
High THC Dose (6% THC)
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place