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Natural History and Risk Factors of TAO

NCT03515863 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2019-09-23

No results posted yet for this study

Summary

The aim of this study is to complete the identification of genetic factors predisposing to thyroid associated ophthalmopathy (TAO) by constituting a cohort of 400 Grave's patients with or without ocular signs.

Conditions

  • Thyroid Associated Ophthalmopathy

Interventions

GENETIC

DNA extraction and genetic characterization

Collection of blood samples for DNA extraction and genetic characterization using whole-genome sequencing, and for identification of cellular biomarkers using transcriptomics and mass cytometry.

DEVICE

Orbit MRI examination

Orbit MRI examination is performed to confirm the diagnosis of TAO

OTHER

Collection of life style data

Collection of life style data using quality of life questionnaire

Sponsors & Collaborators

  • Sun Yat-sen University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-15
Primary Completion
2021-05-09
Completion
2022-05-09

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03515863 on ClinicalTrials.gov