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ROLIVER - Prospective Cohort for the Identification of Liver Microbiota

NCT03511573 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2018-04-30

No results posted yet for this study

Summary

The existence of an adipose tissue microbiota causally involved in the triggering of a low grade inflammation could resemble what observed in liver fibrosis. To generate microbial hypotheses putatively responsible for the onset of liver fibrosis we sequenced the 16SrDNA gene from liver biopsies from 36 obese patients (ROLIVER cohort) and describe an original mathematical approach to decipher signatures of early stage of liver fibrosis F0, F1, F2.

Conditions

  • To Generate Microbial Hypotheses Putatively Responsible for the Onset of Liver Fibrosis

Interventions

PROCEDURE

bariatric and other laparoscopic surgery

We have obtained liver samples during laparoscopic surgical procedures in the majority of cases. The majority of laparoscopic procedures were sleeve gastrectomies performed for morbid obesity as a primary restrictive procedure; in 5 cases the liver biopsies were performed during laparoscopic cholecystectomies.

Sponsors & Collaborators

  • Tîrgu Mureș Emergency Clinical County Hospital, Romania

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-01
Primary Completion
2016-12-31
Completion
2017-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03511573 on ClinicalTrials.gov