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Stratification of Patient With Carotid Disease

NCT03495830 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 270

Last updated 2025-04-06

No results posted yet for this study

Summary

Introduction: Taxinomisis trial is part of the Taxinomisis project. The concept of the Taxinomisis project is to stratify carotid artery disease relying on new modern data corresponding to contemporary patients based on information from longitudinal studies. Taxinomisis trial will validate this tool and adjust such stratification. Initial step of the project is characterization of symptomatic and asymptomatic carotid atherosclerotic plaque lesions, identification of risk and susceptibility factors through the exploitation of longitudinal cohort data and multiomics and disintegration of carotid artery disease phenotypes into endotypes through joint modeling of multipleomics data sets and systems medicine approaches. Finally such stratification model will be validated and adjusted in the Taxinomisis clinical trial.

Conditions

  • Carotid Artery Stenosis

Interventions

PROCEDURE

Carotid endarterectomy

Exploration of carotid bifurcation. Clamping of carotid artery and plaque removal with endarterectomy. Plaque is stored. Suture of artery with direct suture or patch.

Sponsors & Collaborators

  • Ludwig-Maximilians - University of Munich

    collaborator OTHER

  • University of Barcelona

    collaborator OTHER

  • University of Athens

    collaborator OTHER

  • University of Genova

    collaborator OTHER

  • Utrecht University

    collaborator OTHER

  • University of Belgrade

    lead OTHER

Principal Investigators

  • Dimitris Fotiadis, PhD · University of Ionania

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-29
Primary Completion
2022-06-01
Completion
2022-09-01

Countries

  • Germany
  • Netherlands
  • Serbia
  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03495830 on ClinicalTrials.gov