Trial Outcomes & Findings for Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis (NCT NCT03491267)

Last Updated: 2026-06-12

Results Overview

Change in number of new hairs, as assessed by manual counts using ImageJ dermatoscopic images

Recruitment status

COMPLETED

Study phase

EARLY_PHASE1

Target enrollment

24 participants

Primary outcome timeframe

baseline and 9 weeks post treatment (up to 6 months of treatment)

Results posted on

2026-06-12

24 participants were enrolled. 5 participants were lost to attrition before receiving treatment.

Participant milestones
Measure	Subjects With Central Centrifugal Cicatricial Alopecia (CCCA) All patients with Central Centrifugal Cicatricial Alopecia (CCCA) before and after laser and retinoic acid treatment. Patients are assigned treatment on one area, on the left or right side of the scalp on the basis of the individual's alopecia.
Overall Study STARTED	19
Overall Study COMPLETED	13
Overall Study NOT COMPLETED	6

Reasons for withdrawal
Measure	Subjects With Central Centrifugal Cicatricial Alopecia (CCCA) All patients with Central Centrifugal Cicatricial Alopecia (CCCA) before and after laser and retinoic acid treatment. Patients are assigned treatment on one area, on the left or right side of the scalp on the basis of the individual's alopecia.
Overall Study Lost to Follow-up	6

Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis

Baseline characteristics by cohort
Measure	CCCA Patients n=24 Participants All patients with Central centrifugal cicatricial alopecia (CCCA) before and after laser and retinoic acid treatment. Patients are assigned treatment on one area, on the left or right side of the scalp on the basis of the individual's alopecia.
Age, Categorical <=18 years	0 Participants n=9 Participants
Age, Categorical Between 18 and 65 years	20 Participants n=9 Participants
Age, Categorical >=65 years	4 Participants n=9 Participants
Sex: Female, Male Female	24 Participants n=9 Participants
Sex: Female, Male Male	0 Participants n=9 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=9 Participants
Race (NIH/OMB) Asian	0 Participants n=9 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=9 Participants
Race (NIH/OMB) Black or African American	24 Participants n=9 Participants
Race (NIH/OMB) White	0 Participants n=9 Participants
Race (NIH/OMB) More than one race	0 Participants n=9 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=9 Participants

Timeframe: baseline and 9 weeks post treatment (up to 6 months of treatment)

Population: 6 participants were lost to follow-up after receiving treatment. Outcomes were compared pre- and post-treatment per protocol.

Change in number of new hairs, as assessed by manual counts using ImageJ dermatoscopic images

Outcome measures
Measure	Post Treatment n=13 Participants after laser
Change in Number of New Hairs	2.6 hairs Standard Deviation 5.89

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Adverse event data not reported

Other adverse events
Measure	Subjects With Central Centrifugal Cicatricial Alopecia (CCCA) n=19 participants at risk All patients with CCCA before and after laser and retinoic acid treatment. Patients are assigned treatment on one area, on the left or right side of the scalp on the basis of the individual's alopecia.
Skin and subcutaneous tissue disorders mild pruritis and erythema	5.3% 1/19 • from start of treatment up to 9 weeks post-treatment (treatment duration up to 6 months)

Johns Hopkins School of Medicine

Phone: 410-955-5933