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Brain BOLD fMRI in Hypertensive and Normotensive Participants

NCT03473275 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2023-02-21

No results posted yet for this study

Summary

This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the afferent signalling of sympathetic nervous system from the kidney to the brain achieved by renal denervation.

The investigators hypothesize that the change in BOLD signal intensity in response to stress is higher in hypertensive patients than in normotensive subjects and that in patients responsive to renal denervation the change in BOLD signal intensity in response to stress is decreased compared to non-responders or to non-denervated resistant hypertensive patients.

Conditions

  • Hypertension,Essential

Interventions

DIAGNOSTIC_TEST

Cold Pressor test

Both feet in icy waterbath alternated with body temperature water

DIAGNOSTIC_TEST

PinPrick test

Pricking both feet with a needle using gravity (without penetrating) alternated with cotton swap

Sponsors & Collaborators

  • Ecole Polytechnique Fédérale de Lausanne

    collaborator OTHER

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Gregoire Wuerzner, MD · Centre Hospitalier Universitaire Vaudois

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-16
Primary Completion
2022-08-12
Completion
2022-08-12

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03473275 on ClinicalTrials.gov