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Hyponatremia in Elderly Patients With Fractures Around the Hip.

NCT03456492 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2020-10-14

No results posted yet for this study

Summary

Hyponatremia was defined as a serum sodium concentration \<135 mmol/L that occurred at least once during a patient's hospital stay from admission to discharge. Elderly patients with fragility fractures are particularly susceptible to hyponatremia because of their impaired physiology, multiple comorbidities (such as hypocortisolism, hypothyroidism, hepatic cirrhosis, renal disease, and congestive heart failure), polypharmacy (e.g., antihypertensives, antidepressants, and antiepileptics), hospitalization, perioperative fluid restrictions, and homeostatic stress from the fracture itself and the subsequent surgery.

The study has 2 parts:

Part 1: aims to to find incidence of hyponatremia in sample of 70 elderly patients with fractures around the hip, effect of hyponatremia on mental state of the patients by using Modified Mini-Mental state (3MS) examination and to find mortality rate for 6 months post admission.

Part 2: aims to compare sample of 18 elderly hyponatremic patients with fractures around the hip (case group) with sample of 10 elderly normonatremic patients with osteoartharitis of knee or hip who admitted for elective joint replacement (control group) as regards; serum sodium, 3M score, and CSF glutamate to find correlation between the cognitive status assessed by 3M score and CSF glutamate as a biomarker for hyponatremia.

Conditions

  • Hyponatremia in Elderly

Interventions

DIAGNOSTIC_TEST

serum sodium

Serum sodium will be measured on admission, assesment of mental status by Modified Mini-Mental score and measurement of glutamate in CSF sample taken while dripling during spinal anathesia for surgical intervention.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Emad Zarief Kamel, MD · Associate professor of anesthesiology and ICU

  • Mohammed Ismail Sedek, MD · Associate professor of clinical pathology

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-01
Primary Completion
2019-04-01
Completion
2019-06-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03456492 on ClinicalTrials.gov