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Alternation in the Human Microbiome With Commonly Used Topical Medications

NCT03437005 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-02-20

No results posted yet for this study

Summary

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients.

The specific aims are as follows:

1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use.
2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.

Conditions

  • Healthy

Interventions

DRUG

Desonide 0.05%

Desonide 0.05% ointment topically twice daily for two weeks

DRUG

Ketoconazole 2%

Ketoconazole 2% cream topically twice daily for two weeks

Sponsors & Collaborators

  • University of California, Davis

    lead OTHER

Principal Investigators

  • Emanual Maverakis, MD · UC Davis

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-28
Primary Completion
2026-09-28
Completion
2026-09-28
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03437005 on ClinicalTrials.gov