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Maternal EED and Aflatoxin Birth Outcomes Study Uganda

NCT03429257 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 258

Last updated 2018-02-12

No results posted yet for this study

Summary

This prospective cohort study focuses on the relationship between maternal environmental enteric dysfunction (EED) and maternal aflatoxin B1 exposure and birth outcomes, particularly infant anthropometry and gestational age, in Mukono, Uganda.

Conditions

  • Birth Weight
  • Pregnancy Preterm
  • Aflatoxins Toxicity
  • Inflammatory Response

Interventions

OTHER

Exposures of interest: Maternal EED and Aflatoxin Exposure

Maternal EED, measured via lactulose: mannitol (L:M) ratios and serum concentrations of antibodies to the bacterial components flagellin and lipopolysaccharide (LPS); Maternal aflatoxin exposure, measured via serum concentration of AFB1-lysine adduct

Sponsors & Collaborators

  • United States Agency for International Development (USAID)

    collaborator FED

  • Harvard School of Public Health (HSPH)

    collaborator OTHER

  • Tufts University

    lead OTHER

Principal Investigators

  • Shibani Ghosh, PhD · Tufts University Friedman School of Nutrition Science and Policy

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-01
Primary Completion
2017-12-01
Completion
2017-12-01

Countries

  • Uganda

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03429257 on ClinicalTrials.gov