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Pathophysiology of Inborn Immunodeficiencies

NCT03422614 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-05-06

No results posted yet for this study

Summary

The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and/or a deregulated inflammatory response, is poorly understood. Available treatments are often not specific for a distinct target and might be associated with side effects. To elucidate pathophysiology of different PIDs, stool, urine, blood, tissue biopsies and/or bone marrow will be collected and analysed for anti-microbial activity and inflammatory response. In a second step, targeted treatment for different PIDs might be developed preclinically and ex vivo according to underlying pathophysiology.

Conditions

  • Primary Immune Deficiency Disorder

Interventions

DIAGNOSTIC_TEST

Diagnostic Test

Characterisation of cellular and functional phenotype in different PIDs

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Janine Reichenbach, Prof. Dr. · University Children's Hospital, Zurich

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-01
Primary Completion
2033-03-30
Completion
2033-03-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03422614 on ClinicalTrials.gov