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Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy

NCT03410576 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2018-01-25

No results posted yet for this study

Summary

The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS). The investigators used a matched, historical carotid endarteriectomy group as controls. Blood samples at four time points: T1: preoperative; T2: 60 minutes after stent insertion; T3: first postoperative morning; and T4: third postoperative morning. Plasma was isolated from heparin anticoagulated blood samples by low speed centrifugation at 4 °C, and stored at -80 °C until analyzed in a single batch at the end of the study. Plasma concentrations of MMP-9 and TIMP-1 were expressed as ng/ml.

Conditions

  • Carotid Stenosis
  • Ischemia Reperfusion Injury

Interventions

PROCEDURE

Carotid artery stenting

Patient undergo elective carotid artery stenting. In this patient group blood sampling was performed at three time points: T1, at the time of the insertion of the arterial line; T2, 60 min after stent insertion; and T3: the first postoperative morning.

PROCEDURE

Carotid endarterectomy

Patient undergo elective carotid endarterectomy. Group samples were collected at the following four time points: T1, at the time of the insertion of the arterial line; T2, 60 min after cross-clamp release; T3, the first postoperative morning; and T4, the third postoperative morning. A matched subgroup of patients from the previously obtained data served as a historical control.

Sponsors & Collaborators

  • University of Pecs

    lead OTHER

Principal Investigators

  • Gábor Woth, MD, PhD · Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs

  • Bálint Nagy, MD, PhD · Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs

  • Diana Mühl, MD, PhD · Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs

  • János Lantos, PhD · Department of Surgical Research and Techniques, Medical School, University of Pécs,

  • Ferenc Kövér, MD · Department of Neurosurgery, Medical School, University of Pécs,

  • Lajos Bogár, MD, DsC · Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-10-01
Primary Completion
2015-11-30
Completion
2015-11-30

Countries

  • Hungary

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03410576 on ClinicalTrials.gov