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Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD

NCT03388385 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-08-16

No results posted yet for this study

Summary

The purpose of this study is to investigate the effects of acute intravenous iron administration on the endothelial function in non-dialysis Chronic Kidney Disease stages G3-G5 patients with anemia and iron deficiency, in relation to changes in oxidative and nitrosative status.

Conditions

  • Renal Anemia
  • Iron Toxicity
  • Oxidative Stress
  • Endothelial Dysfunction

Interventions

DRUG

Sodium Chloride 0.9% Intravenous Solution

Physiologic saline infusion will be infused in day 1.

DRUG

Ferinject

Ferric carboxymaltose will be infused in day 2.

Sponsors & Collaborators

  • S.C. Sanador S.R.L

    collaborator OTHER

  • Carol Davila University of Medicine and Pharmacy

    lead OTHER

Principal Investigators

  • Gabriel Mircescu, Professor · Carol Davila University of Medicine and Pharmacy

  • Cristina Capusa, Assoc. Prof. · Carol Davila University of Medicine and Pharmacy

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-20
Primary Completion
2020-12-30
Completion
2022-12-20

Countries

  • Romania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03388385 on ClinicalTrials.gov