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Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial)

NCT03372811 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 88

Last updated 2026-03-25

Study results available
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Summary

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase IIb Clinical Trial to Evaluate the Efficacy and Safety of a Botanical Total Coumarin Cream (TC) in Treating Patients with Psoriasis Vulgaris

Conditions

  • Psoriasis Vulgaris
  • Topical Administration

Interventions

DRUG

Total coumarin (TC) cream

A well-characterized botanical drug for the topical treatment of psoriasis vulgaris. The drug has been approved by the NMPA in China and has obtained an NDA following multiple clinical trials spanning phases I-III in large cohorts.

DRUG

Vehicle

Vehicle

Sponsors & Collaborators

  • Psoriasis Research Institute of Guangzhou

    lead INDUSTRY

Principal Investigators

  • Edward Heilman, MD · Department of Dermatology, State University of New York

  • Peter J. Jenkin, MD · Dermatology Associates

  • Jiang Yang, Ph.D. · Psoriasis Research Institute of Guangzhou

  • Liping Yang, MD · Psoriasis Research Institute of Guangzhou

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-11
Primary Completion
2018-03-14
Completion
2018-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03372811 on ClinicalTrials.gov