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The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome

NCT03345030 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2017-11-24

No results posted yet for this study

Summary

Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by comet assay in unexplained infertile patients undergoing in vitro fertilization (IVF) treatment. The oocytes will be graded by particular criteria. Fertilization, embryo quality, transfer rate, implantation, clinical pregnancy, pregnancy outcomes (gestational age at delivery, route of delivery, and birthweight etc.) will be recorded as well as demographic data. DNA damage of granulosa cells will be compared between unexplained infertile and control groups. The effect of DNA damage of granulosa cells on fertilization, quality of oocyte and embryo, implantation, and clinical pregnancy will be also evaluated.

Conditions

  • in Vitro Fertilization

Sponsors & Collaborators

  • Suleyman Demirel University

    lead OTHER

Principal Investigators

  • ESRA NUR TOLA · Suleyman Demirel Univercity, Medicine Faculty, Department of Gyneacology and Obstetrics

Eligibility

Min Age
19 Years
Max Age
44 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-09
Primary Completion
2018-01-30
Completion
2018-03-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03345030 on ClinicalTrials.gov