Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease

Summary

The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active substances in volunteers with subjective (SCI) or mild (MCI) cognitive impairment, as well as in patients in early stages of Parkinson's disease. The investigators assume the immediate intervention-associated health benefit for volunteers.

Conditions

• Subjective Cognitive Impairment
• Mild Cognitive Impairment
• Parkinson Disease
• Healthy Volunteers

Interventions

BEHAVIORAL

exercise

participants will be subjected to 4 months supervised exercise intervention

DIETARY_SUPPLEMENT

carnosine supplementation

participants will be instructed to take carnosine 2 times daily

BEHAVIORAL

stretching

participants will be subjected to 4 months supervised stretching program

DIETARY_SUPPLEMENT

supplementation with placebo

participants will be instructed to take placebo 2 times daily

Sponsors & Collaborators

• Comenius University

  collaborator OTHER

• University Hospital Bratislava

  collaborator OTHER

• National Cheng Kung University

  collaborator OTHER

• Slovak Academy of Sciences

  lead OTHER_GOV

Principal Investigators

• Peter Turčáni, Prof., MD, PhD · University Hospital Bratislava, Comenius University, Bratislava,

• Peter Valkovič, Prof., MD, PhD · University Hospital Bratislava, Comenius University, Bratislava,

• Barbara Ukropcová, Assoc. Prof., MD, PhD · Biomedical Research Center, Slovak Academy of Sciences,

• Jozef Ukropec, DrSc, PhD · Biomedical Research Center, Slovak Academy of Sciences,

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

55 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-01-01

Primary Completion

2023-06-30

Completion

2023-09-30

Countries

• Slovakia
• Taiwan

Study Locations