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Pregnancy Related Inappropriate Sinus Tachycardia

NCT03317249 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2019-01-22

No results posted yet for this study

Summary

A feasibility study into the exploration of possible mechanisms underlying inappropriate sinus tachycardia (IST) syndrome in pregnancy.

Conditions

  • Inappropriate Sinus Tachycardia
  • Pregnancy Related

Interventions

DIAGNOSTIC_TEST

ECG

12-lead electrocardiogram

DIAGNOSTIC_TEST

heart rate monitor

24-hour heart rate monitor used to calculate mean heart rate and heart rate variability

DIAGNOSTIC_TEST

Autonomic Nervous System (ANS) Activity

Heart Rate Variability (HRV) and Baroreflex sensitivity (BRS): Resting and exercise HRV and BRS calculated from ECG, Dundee Step test and blood pressure measurements.

DIAGNOSTIC_TEST

Haemodynamic variables

Cardiac output (CO), stroke volume (SV) and systematic vascular resistance (SVR) will be assessed and calculated using a non-invasive, inert gas re-breathing technique whereby expired gases will be sampled and analysed alongside and blood pressure measurements.

OTHER

Echocardiogram

optional (for non-IST participants only)

Sponsors & Collaborators

  • Cambridge University Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Mark Belham · Cambridge University Hospitals NHS Foundation Trust

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-10-06
Primary Completion
2020-10-06
Completion
2020-10-06

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03317249 on ClinicalTrials.gov