Trial Outcomes & Findings for Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male (NCT NCT03282682)
NCT ID: NCT03282682
Last Updated: 2021-07-30
Results Overview
Total body by Dual-energy X-ray Absorptiometry using Hologic fan-beam bone densitometer Discovery QDR series.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
22 participants
Primary outcome timeframe
7 days before intervention, 7 days after intervention
Results posted on
2021-07-30
Participant Flow
Participant milestones
| Measure |
Hypogonadal Males Without TRT
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Overall Study
STARTED
|
6
|
8
|
8
|
|
Overall Study
COMPLETED
|
6
|
8
|
8
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male
Baseline characteristics by cohort
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Total
n=22 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
48.41 years
STANDARD_DEVIATION 7.9 • n=99 Participants
|
43.03 years
STANDARD_DEVIATION 2.9 • n=107 Participants
|
50.11 years
STANDARD_DEVIATION 5.1 • n=206 Participants
|
47.07 years
STANDARD_DEVIATION 7.15 • n=7 Participants
|
|
Sex: Female, Male
Female
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
0 Participants
n=7 Participants
|
|
Sex: Female, Male
Male
|
6 Participants
n=99 Participants
|
8 Participants
n=107 Participants
|
8 Participants
n=206 Participants
|
22 Participants
n=7 Participants
|
|
Race/Ethnicity, Customized
Slovak
|
6 participants
n=99 Participants
|
8 participants
n=107 Participants
|
8 participants
n=206 Participants
|
22 participants
n=7 Participants
|
|
Region of Enrollment
Slovakia
|
6 participants
n=99 Participants
|
8 participants
n=107 Participants
|
8 participants
n=206 Participants
|
22 participants
n=7 Participants
|
PRIMARY outcome
Timeframe: 7 days before intervention, 7 days after interventionTotal body by Dual-energy X-ray Absorptiometry using Hologic fan-beam bone densitometer Discovery QDR series.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Lean Mass
|
2734 grams
Standard Deviation 1967
|
499 grams
Standard Deviation 1566
|
2268 grams
Standard Deviation 2609
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionTotal body by Dual-energy X-ray Absorptiometry using Hologic fan-beam bone densitometer Discovery QDR series.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Fat Mass
|
-1969 grams
Standard Deviation 2526
|
-1263 grams
Standard Deviation 1920
|
-755 grams
Standard Deviation 1514
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionTotal body by Dual-energy X-ray Absorptiometry using Hologic fan-beam bone densitometer Discovery QDR series.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Total Body Mass
|
621.53 grams
Standard Deviation 2922.45
|
-821.73 grams
Standard Deviation 3279.29
|
1435.04 grams
Standard Deviation 3655.01
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured in seconds by Microgates Photocells and than calculated to meters per second.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in 10-m Usual Walk Test
|
0 m/s
Standard Deviation 0.089
|
-0.06 m/s
Standard Deviation 0.146
|
-0.05 m/s
Standard Deviation 0.136
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured in seconds by Microgates Photocells than calculated to meters per second
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in 10-m Fast Walk Test
|
0.05 m/s
Standard Deviation 0.255
|
-0.1 m/s
Standard Deviation 0.172
|
-0.13 m/s
Standard Deviation 0.253
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured by Camry Digital Hand Dynamometer.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Handgrip Strength
|
-1.41 kg
Standard Deviation 4.00
|
0.84 kg
Standard Deviation 2.12
|
-0.02 kg
Standard Deviation 3.28
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured by Portable Isometric Knee Dynamometer.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Extension
|
-9.65 Nm
Standard Deviation 93.44
|
8.15 Nm
Standard Deviation 28.97
|
1.35 Nm
Standard Deviation 69.50
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured by Portable Isometric Knee Dynamometer.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Maximal Voluntary Contraction (MVC) of Isometric Knee Flexion
|
2.32 Nm
Standard Deviation 27.89
|
24.64 Nm
Standard Deviation 36.09
|
14.36 Nm
Standard Deviation 28.13
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionThis test is focused on calculated VO2max in ml.kg-1.min-1 from speed measured on Woodway Pro Treadmill.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in The Single Stage Treadmill Walking Test
|
0.61 ml.kg-1.min-1
Standard Deviation 0.64
|
0.25 ml.kg-1.min-1
Standard Deviation 0.64
|
0.42 ml.kg-1.min-1
Standard Deviation 0.54
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionOne repetition maximum in kg on leg press is predicted from multiple repetition maximum testing and measured on Life Fitness Signature Series Leg Press machine.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Predicted One Repetition Maximum on Leg Press
|
45.31 kg
Standard Deviation 28.39
|
51.59 kg
Standard Deviation 34.43
|
51.40 kg
Standard Deviation 27.16
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasured in N by FiTRO Force Plates.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Maximal Voluntary Contraction in Benchpress
|
-6.49 N
Standard Deviation 147.12
|
64.31 N
Standard Deviation 143.29
|
66.68 N
Standard Deviation 103.38
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionPatient-reported survey of patient health (SF-36), clinically investigating the health-related quality of life (HRQoL). The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability. The items contributing to a scale are scored so that a higher score represents better health, and they are averaged together to create the scale score.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in The Short Form Health Survey (SF-36)
|
2.50 score on a scale
Standard Deviation 9.87
|
7.50 score on a scale
Standard Deviation 18.52
|
3.75 score on a scale
Standard Deviation 12.46
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionMeasuring symptoms of ageing men by numeric score scale. The questionnaire has for each of the 17 item an option to check one of 5 degrees of severity (severity 1...5 points at the questionnaire). The composite scores for each of the three dimensions (sub-scales) is based on adding up the scores of the items of the respective dimensions. The composite score (total score) is the sum of the three dimension scores. Higher score means higher severity of symptoms. The minimum total score is 17 and the maximum is 85.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Aging Males' Symptom (AMS) Scale
|
-4.83 score on a scale
Standard Deviation 7.41
|
-2.00 score on a scale
Standard Deviation 5.98
|
-6.25 score on a scale
Standard Deviation 5.09
|
SECONDARY outcome
Timeframe: 7 days before intervention, 7 days after interventionFasting morning venous blood was taken after overnight (10-hour) fasting and 15 min rest from cubital vein from 8:00 am to 10:00 am \[69\] into closed system collection tubes containing beads coated with a clotting activator and polyacryl ester-gel (Sarstedt AG \& Co, Germany). The blood will be centrifuged (3000g, 4°C, 10min) immediately after sampling to obtain EDTA plasma or they will be centrifuged (3000g, 4°C, 20min) after 30min at RT, to obtain serum.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Metabolic Parameters
S-Triglyceride
|
-0.20 mmol/l
Standard Deviation 0.46
|
0.38 mmol/l
Standard Deviation 1.27
|
0.28 mmol/l
Standard Deviation 0.86
|
|
Change From Baseline in Metabolic Parameters
S-Urea
|
-0.16 mmol/l
Standard Deviation 1.45
|
3.77 mmol/l
Standard Deviation 8.58
|
0.84 mmol/l
Standard Deviation 1.26
|
|
Change From Baseline in Metabolic Parameters
S-Uric Acid
|
-0.016 mmol/l
Standard Deviation 0.071
|
0.004 mmol/l
Standard Deviation 0.047
|
-0.010 mmol/l
Standard Deviation 0.053
|
|
Change From Baseline in Metabolic Parameters
S-Bilirubin
|
0.0006 mmol/l
Standard Deviation 0.0038
|
0.0008 mmol/l
Standard Deviation 0.004
|
-0.003 mmol/l
Standard Deviation 0.006
|
|
Change From Baseline in Metabolic Parameters
S-Creatinine
|
-0.006 mmol/l
Standard Deviation 0.008
|
-0.0002 mmol/l
Standard Deviation 0.0052
|
0.0011 mmol/l
Standard Deviation 0.0038
|
|
Change From Baseline in Metabolic Parameters
S-Glucose
|
0.33 mmol/l
Standard Deviation 0.44
|
0.29 mmol/l
Standard Deviation 0.50
|
-0.02 mmol/l
Standard Deviation 0.65
|
|
Change From Baseline in Metabolic Parameters
S-Total Cholesterol
|
0.10 mmol/l
Standard Deviation 0.67
|
0.22 mmol/l
Standard Deviation 0.71
|
0.29 mmol/l
Standard Deviation 1.11
|
|
Change From Baseline in Metabolic Parameters
S-HDL Cholesterol
|
0.06 mmol/l
Standard Deviation 0.10
|
0.09 mmol/l
Standard Deviation 0.17
|
0.08 mmol/l
Standard Deviation 0.20
|
|
Change From Baseline in Metabolic Parameters
S-LDL Cholesterol
|
-0.06 mmol/l
Standard Deviation 0.52
|
-0.30 mmol/l
Standard Deviation 1.07
|
-0.12 mmol/l
Standard Deviation 0.84
|
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionFasting morning venous blood was taken after overnight (10-hour) fasting and 15 min rest from cubital vein from 8:00 am to 10:00 am \[69\] into closed system collection tubes containing beads coated with a clotting activator and polyacryl ester-gel (Sarstedt AG \& Co, Germany). The blood will be centrifuged (3000g, 4°C, 10min) immediately after sampling to obtain EDTA plasma or they will be centrifuged (3000g, 4°C, 20min) after 30min at RT, to obtain serum.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Liver Function Blood Parameters
S-ALP
|
0.06 µkat/l
Standard Deviation 0.11
|
0.05 µkat/l
Standard Deviation 0.11
|
0.10 µkat/l
Standard Deviation 0.18
|
|
Change From Baseline in Liver Function Blood Parameters
S-ALT
|
0.19 µkat/l
Standard Deviation 0.49
|
-0.05 µkat/l
Standard Deviation 0.28
|
-0.07 µkat/l
Standard Deviation 0.10
|
|
Change From Baseline in Liver Function Blood Parameters
S-AMS
|
0.06 µkat/l
Standard Deviation 0.23
|
0.05 µkat/l
Standard Deviation 0.08
|
0.07 µkat/l
Standard Deviation 0.16
|
|
Change From Baseline in Liver Function Blood Parameters
S-AST
|
0.05 µkat/l
Standard Deviation 0.19
|
0.00 µkat/l
Standard Deviation 0.19
|
-0.01 µkat/l
Standard Deviation 0.04
|
|
Change From Baseline in Liver Function Blood Parameters
S-GMT
|
-0.13 µkat/l
Standard Deviation 0.23
|
0.01 µkat/l
Standard Deviation 0.16
|
-0.05 µkat/l
Standard Deviation 0.27
|
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionFasting morning venous blood was taken after overnight (10-hour) fasting and 15 min rest from cubital vein from 8:00 am to 10:00 am \[69\] into closed system collection tubes containing beads coated with a clotting activator and polyacryl ester-gel (Sarstedt AG \& Co, Germany). The blood will be centrifuged (3000g, 4°C, 10min) immediately after sampling to obtain EDTA plasma or they will be centrifuged (3000g, 4°C, 20min) after 30min at RT, to obtain serum.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Hormonal Parameters
S-Testosterone
|
1.69 nmol/l
Standard Deviation 1.20
|
-0.50 nmol/l
Standard Deviation 3.51
|
-1.99 nmol/l
Standard Deviation 2.59
|
|
Change From Baseline in Hormonal Parameters
S-SHBG
|
2.42 nmol/l
Standard Deviation 4.67
|
-1.35 nmol/l
Standard Deviation 6.10
|
-2.93 nmol/l
Standard Deviation 6.55
|
|
Change From Baseline in Hormonal Parameters
S-Cortisol
|
-32.93 nmol/l
Standard Deviation 103.28
|
-44.60 nmol/l
Standard Deviation 140.83
|
34.34 nmol/l
Standard Deviation 159.29
|
|
Change From Baseline in Hormonal Parameters
S-Insuline
|
0.004 nmol/l
Standard Deviation 0.046
|
0.019 nmol/l
Standard Deviation 0.061
|
0.006 nmol/l
Standard Deviation 0.023
|
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionFasting morning venous blood was taken after overnight (10-hour) fasting and 15 min rest from cubital vein from 8:00 am to 10:00 am \[69\] into closed system collection tubes containing beads coated with a clotting activator and polyacryl ester-gel (Sarstedt AG \& Co, Germany). The blood will be centrifuged (3000g, 4°C, 10min) immediately after sampling to obtain EDTA plasma or they will be centrifuged (3000g, 4°C, 20min) after 30min at RT, to obtain serum.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in Ions
S-Chlorides
|
-1.47 mmol/l
Standard Deviation 2.50
|
-0.77 mmol/l
Standard Deviation 4.21
|
-0.33 mmol/l
Standard Deviation 3.78
|
|
Change From Baseline in Ions
S-Potassium
|
0.17 mmol/l
Standard Deviation 0.34
|
0.06 mmol/l
Standard Deviation 0.13
|
0.14 mmol/l
Standard Deviation 0.31
|
|
Change From Baseline in Ions
S-Sodium
|
0.08 mmol/l
Standard Deviation 1.26
|
-0.15 mmol/l
Standard Deviation 1.31
|
-0.19 mmol/l
Standard Deviation 1.13
|
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionFasting morning venous blood was taken after overnight (10-hour) fasting and 15 min rest from cubital vein from 8:00 am to 10:00 am \[69\] into closed system collection tubes containing beads coated with a clotting activator and polyacryl ester-gel (Sarstedt AG \& Co, Germany). The blood will be centrifuged (3000g, 4°C, 10min) immediately after sampling to obtain EDTA plasma or they will be centrifuged (3000g, 4°C, 20min) after 30min at RT, to obtain serum.
Outcome measures
| Measure |
Hypogonadal Males Without TRT
n=6 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Hypogonadal Males With TRT
n=8 Participants
Strength training and regular prescribed testosterone therapy given by participant urologist.
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
Healthy Eugonadal Males
n=8 Participants
Strength training
Strength training: The participants perform strength training sessions two times per week for 12 weeks. Each training session include 5-minute general dynamic warm-up followed by progressive strength training with exercises for the entire body. The strength exercises are performed with free weights and on machines. The training program consist of 6 exercises for upper and lower body at an intensity of 60-80% (8 - 12RM: the load that induces technique failure in eight or twelve repetitions) of one-repetition maximum and takes approximately 60 minutes. The exercises performed are: leg press, split squats, bench press, knee extension, knee flexion, seated cable rows, seated cable pull downs, dumbbell bench press, incline dumbbell bench press.
|
|---|---|---|---|
|
Change From Baseline in CRP
|
0.02 mg/l
Standard Deviation 9.40
|
0.13 mg/l
Standard Deviation 2.26
|
-1.67 mg/l
Standard Deviation 2.40
|
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionMuscle fiber size measured in um2. Analysis of the date are in progress.
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 7 days before intervention, 14 days after interventionRegulators of muscle fiber size - number of myonuclei per muscle fiber, number of satellite cells per muscle fiber, number of satellite cells and myonuclei positive for androgen receptors, proteins involved in muscle hypertrophy. Analysis of the date are in progress.
Outcome measures
Outcome data not reported
Adverse Events
Hypogonadal Males Without TRT
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Hypogonadal Males With TRT
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy Eugonadal Males
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Doc. Mgr. Milan Sedliak, PhD.
Comenius University in Bratislava
Phone: +421918340671
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place