Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System

Summary

Apathy is defined as a quantitative reduction in voluntary and goal-directed behavior. To address this, the investigators propose an ethological approach to assess apathy objectively and quantitatively by observing patients in real-life situations.

The ECOCAPTURE paradigm involves a structured, multi-step scenario conducted in a functional exploration platform. This platform is equipped with an advanced data acquisition system integrating video recordings and sensors to precisely monitor and analyze participants' behavior.

Primary objective:

Develop a diagnostic tool for apathy using metrics derived from video recordings and sensor data. This tool aims to provide objective measures to identify and quantify apathy.

Secondary Objectives:

* Validation of ICM\_APATHY\_TASKS: This novel experimental task is designed to evaluate three primary mechanisms thought to underlie apathy: Motivation, Cognitive inertia (difficulty initiating tasks), The interaction between motivation and action execution.
* Identification of the pathophysiological mechanisms of apathy by investigate the cognitive, behavioral, neural, and neurohormonal underpinnings of apathy.

This will enable the classification of apathetic patients into subtypes (or several forms of apathy) based on the dominant mechanisms and provide insights into which processes best explain apathy in individual cases.

This innovative framework aims to deepen the understanding of apathy, improve diagnostic precision, and pave the way for tailored interventions.

Conditions

• Apathy
• Behavioral Variant Frontotemporal Dementia (bvFTD)
• Disinhibition
• Depression - Major Depressive Disorder

Interventions

BEHAVIORAL

ECOCAPTURE

45 minutes observational session for tracking goal directed behavior into a waiting room equipped with video and sensor-based data acquisition system

BEHAVIORAL

Cognitive and Behavioral experimental tasks

Cognitive and Behavioral experimental tasks to explore additional frontal cognitive and behavioral dimensions and functions

DIAGNOSTIC_TEST

Neuropsychological assessment

STARKSTEIN APATHY SCALE (SAS) / DAS / MMSE / MADRS / EBI / MINI-SEA / FAB / HAD / MATTIS / HAYLING / STROOP / Verbal Span / Lexical verbal fluency / TMT / CDRS

BEHAVIORAL

ICM_APATHY_TASKS

Apathy experimental task

OTHER

MRI

T1 / T2 / rs-fMRI / MS-DWI

BIOLOGICAL

Neurohormonal mechanisms

Hormonal dosage / Diabetic dosage / Ionogramme dosage / Inflammatory dosage / Hepatic dosage / Lipidic dosage / Thyroid dosage

Sponsors & Collaborators

• Institut du Cerveau et de la Moelle (ICM Institute)

  collaborator UNKNOWN

• Groupe Hospitalier Pitie-Salpetriere

  collaborator OTHER

• Institut National de la Santé Et de la Recherche Médicale, France

  lead OTHER_GOV

Principal Investigators

• Richard LEVY, MD, PhD · Assistance Publique - Hôpitaux de Paris

• Bénédicte BATRANCOURT, PhD · Institut National de la Santé Et de la Recherche Médicale, France

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-09-06

Primary Completion

2023-12-08

Completion

2024-05-08

Countries

• France

Study Locations