Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma
NCT03271632 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2019-09-19
Summary
The aim of this clinical trial is to assess the feasibility, safety and efficacy of autologous CAR T cell immunotherapy targeting multiple cancer cell surface antigens in relapsed and refractory multiple myeloma patients. Another goal of the study is to learn more about the persistence and function of CAR T cells in the body.
Conditions
Interventions
- BIOLOGICAL
-
CAR T cells
Infusion of multi-CAR T cells
Sponsors & Collaborators
-
Shenzhen Geno-Immune Medical Institute
lead OTHER
Principal Investigators
-
Lung-Ji Chang · Shenzhen Geno-Immune Medical Institute
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-07-15
- Primary Completion
- 2019-12-31
- Completion
- 2020-12-31
Countries
- China
Study Locations
More Related Trials
-
Clinical Trial to Evaluate CT053 in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 1)
NCT03975907 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
B Cell Maturation Antigen Targeted CAR-T Cells in Treatment With Relapsed and Refractory Multiple Myeloma
NCT05150522 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma
NCT06581640 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Trial to Evaluate the Safety and Efficacy of IM21 CAR-T Cells in Patients With Relapsed and Refractory (R/R) Multiple Myeloma
NCT05478343 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CAR-T Cells in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT04626752 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refractory Multiple Myeloma
NCT07032129 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies
NCT04033302 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of C-CAR088 in Patients With Relapsed or Refractory Multiple Myeloma
NCT05521802 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CAR-T Cells Therapy in Relapsed/Refractory Multiple Myeloma
NCT03473496 ·Status: TERMINATED ·Phase: NA
-
Dual-target CAR-T Cells (C-4-29) in the Treatment of Relapsed/Refractory Multiple Myeloma
NCT04861480 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Trial of BCMA CAR T Cell Infusion in Patients With BCMA-positive r/r Multiple Myeloma
NCT04186052 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CAR-T Cell Therapy Combined With Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Refractory Multiple Myeloma
NCT06913179 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT03751293 ·Status: UNKNOWN ·Phase: PHASE1
-
Targeting CD19 and BCMA CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Multiple Myeloma
NCT04714827 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Frontline Combination CAR-T Cell Therapy for Multiple Myeloma or Plasmacytoma
NCT06429150 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT04295018 ·Status: UNKNOWN ·Phase: PHASE1
-
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
NCT07106736 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study of CAR-BCMA T Cells in Patients With Refractory or Relapsed Multiple Myeloma
NCT03380039 ·Status: UNKNOWN ·Phase: NA
-
CAR-T Re-treatment for Refractory/Relapsed Multiple Myeloma
NCT03672253 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Access the Safety and Efficacy of CT0590 in Patients With Relapsed and/or Refractory Multiple Myeloma
NCT05066022 ·Status: UNKNOWN ·Phase: NA
-
Clinical Study to Evaluate the Safety and Feasibility of spCART-269 Injection in the Treatment of MM
NCT04500431 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of DeepTag-GPRC5D Targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
NCT06084962 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Anti-BCMA CAR-T Therapy in Newly Diagnosed Myeloma Patients Who Are Transplant-ineligible
NCT07070960 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma
NCT03758417 ·Status: TERMINATED ·Phase: PHASE2
-
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies
NCT03638206 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2