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Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients

NCT03271268 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2017-09-07

No results posted yet for this study

Summary

Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock. However, fluid rescucitation can lead to fluid overload, which manifests most notably as lung edema.

The peptide NT-pro-BNP, a biomarker of cardiac congestion secreted by the myocardium, as well as plasma CD146, an endothelial factor involved in angiogenesis and a marker of vascular congestion, may help identifying patients with risk of pulmonary edema and hypoxia .

Our hypothesis is that these biomarkers may predict the occurence of pulmonary edema in severe burns patients.

Conditions

  • Burns

Sponsors & Collaborators

  • Saint-Louis Hospital, Paris, France

    lead OTHER

Principal Investigators

  • Sabri Soussi, MD · Saint-Louis Hospital, Paris, France

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-06
Primary Completion
2019-02-06
Completion
2019-04-06

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03271268 on ClinicalTrials.gov