Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections

Summary

This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns. The objective of this study is to analyze the correlation between PROM and early-onset neonatal infections and to assess the prognosis of newborns. A cohort study is designed to implement the study. The subjects of study group are pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks. The subjects of control group are pregnant women without PROM and chorioamnionitis. Control group and research group are paired at 1: 1 ratio. The main contents of the study include three aspects. (1) The correlation between PROM and chorioamnionitis. (2) The correlation between PROM and early-onset neonatal infections. (3) The pathogenesis of intrauterine infection and neonatal infection.

Conditions

• Premature Rupture of Membrane
• Neonatal Infection

Sponsors & Collaborators

• Northwest Women's and Children's Hospital, Xi'an, Shaanxi

  collaborator OTHER

• Chengdu Women's and Children's Central Hospital

  collaborator OTHER

• Shenzhen Maternity & Child Healthcare Hospital

  collaborator OTHER

• Nanjing Maternity and Child Health Care Hospital

  collaborator OTHER

• Shenzhen Bao'an Maternal and Child Health Hospital

  collaborator OTHER

• Second Hospital of Jilin University

  collaborator OTHER

• Bayi Children's Hospital Affiliated to PLA Army General Hospital, China

  lead OTHER

Principal Investigators

• Xing Li · Bayi Children's Hospital Affiliated to PLA Army General Hospital, China

• Shaodong Hua · Bayi Children's Hospital Affiliated to PLA Army General Hospital, China

• Jie Cui · Bayi Children's Hospital Affiliated to PLA Army General Hospital, China

• Lei Li · Bayi Children's Hospital Affiliated to PLA Army General Hospital, China

Eligibility

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-08-15

Primary Completion

2018-03-31

Completion

2018-04-30

Countries

• China

Study Locations