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Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.

NCT03248076 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2017-12-14

No results posted yet for this study

Summary

Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome.

This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during oocyte retrieval.

Conditions

  • Stress Reaction
  • Opioid Use

Interventions

DRUG

Fentanyl Citrate

1γ/Kg fentanyl

Sponsors & Collaborators

  • Papanikolaou Evaggelos

    collaborator UNKNOWN

  • Naidecki Robert

    collaborator UNKNOWN

  • Pakaki Fay

    collaborator UNKNOWN

  • Raikos Nikolaos

    collaborator UNKNOWN

  • George Papanicolaou Hospital

    lead OTHER

Principal Investigators

  • Irene Asouhidou, MD, PhD · Assisting Nature

Eligibility

Min Age
18 Years
Max Age
32 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-04-01
Primary Completion
2018-08-31
Completion
2018-10-10

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03248076 on ClinicalTrials.gov