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Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .

NCT03238430 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 186

Last updated 2025-12-22

No results posted yet for this study

Summary

Analgesia in liver surgery is a challenge, postoperative coagulopathy risk raises fears an epidural haematoma formation following the epidural analgesia, "gold standard" in major abdominal surgery. The spinal analgesia and/or continuous wound infiltration of local anesthetics constitute so an alternative.

The study will compare the continuous infiltration of local anesthetics and rachianalgesia in terms of decreased postoperative morphine consumption and incidences of chronic postoperative pain at 3 and 6 months after hepatic surgery compared to the control group.

Conditions

  • Pain, Postoperative

Interventions

DRUG

intrathecal morphine

A single intrathecal injection of 300 micrograms of Morphine preoperatively, just before induction.

DRUG

Morphine PCA

a postoperative Morphine PCA

DRUG

Ropivacaine infiltration

Ropivacaine 2mg / ml at the rate of 8ml per hour via a multiperforated catheter with connector after bolus of 20 ml

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Gilles Lebuffe, MD, PhD · CHRU de Lille

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-20
Primary Completion
2019-05-25
Completion
2019-05-25

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03238430 on ClinicalTrials.gov