Apatinib Combined With Chemotherapy for Esophageal Squamous Cell Cancer After the Failure of Standard Treatment
NCT03224221 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 189
Last updated 2017-07-21
Summary
We conduct the clinical trial to further explore the efficacy and safety of Apatinib combined with chemotherapy in treating recurrent or metastatic esophageal squamous cell carcinoma after the failure of conventional treatments.
Conditions
Interventions
- DRUG
-
Apatinib
Patients will receive Apatinib at 500mg/times,oral one times daily for 28 days
- DRUG
-
fluorouracil and platinum
the dosage of the fluorouracil and platinum need to be determined by the doctors according to the actual condition of the patients
Sponsors & Collaborators
-
The First Affiliated Hospital of Anhui Medical University
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-03-23
- Primary Completion
- 2019-01-23
- Completion
- 2019-06-23
Countries
- China
Study Locations
More Related Trials
-
Apatinib in the Treatment of Recurrence or Metastasis of Esophageal Cancer
NCT03913182 ·Status: UNKNOWN ·Phase: PHASE2
-
Afatinib Plus Toripalimab in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification
NCT04880811 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib Treatment for Advanced Esophagus Cancer
NCT03170310 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib and Irinotecan Combination Treatment in Unresectable or Metastatic Esophageal Squamous Cell Carcinoma
NCT03251417 ·Status: TERMINATED ·Phase: PHASE2
-
Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma
NCT06281886 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell Carcinoma
NCT06753747 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
An Exploratory Clinical Study of Apatinib for the 2nd Treatment of Esophageal Cancer or Esophageal and Gastric
NCT03285906 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Adbelimumab Combined With Chemotherapy and Apatinib in Patients With Resectable Esophageal Squamous Cell Carcinoma
NCT06576973 ·Status: RECRUITING ·Phase: PHASE2
-
Apatinib as First -Line Treatment for Advanced Esophagus Cancer
NCT03542422 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Apatinib Plus Radiotherapy and S-1 for Treatment of Refractory or Metastatic Esophageal Squamous Cell Carcinoma
NCT03320629 ·Status: TERMINATED ·Phase: PHASE2
-
The Phase II Trial of SHR-1210 Combined With Preoperative Chemotherapy or Apatinib for Locally Advanced ESCC
NCT03917966 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase II Exploratory Clinical Trial of Multiple Drug Combinations in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
NCT03736863 ·Status: RECRUITING ·Phase: PHASE2
-
Carrelizumab, Chemotherapy and Apatinib in the Neoadjuvant Treatment of Resectable Esophageal Squamous Cell Carcinoma
NCT04666090 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study of Apatinib in Metastatic Esophageal Cancer
NCT02683655 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma
NCT07142421 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
JMT101 Combined With Afatinib in Patients With Advanced Esophageal Squamous Cell Carcinoma After Standard Therapy
NCT05164848 ·Status: UNKNOWN ·Phase: PHASE1
-
mFOLFIRI as the Second Line Chemotherapy for Advanced Esophageal Carcinoma After Failure of 1st Line Treatment of Paclitaxel/DDP : a Phase II Single Center Prospective Clinical Trial
NCT01044420 ·Status: UNKNOWN ·Phase: PHASE2
-
Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction
NCT05865132 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Chemoradiotherapy Combined With Perioperative Toripalimab in Locally Advanced Esophageal Cancer
NCT04437212 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib for Metastatic Esophageal Cancer.
NCT02544737 ·Status: UNKNOWN ·Phase: PHASE2
-
Nimotuzumab,Camrelizumab, and Neoadjuvant Chemotherapy(nCT) in the Treatment of Esophageal Squamous Cell Carcinoma
NCT07312578 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2
-
Camrelizumab in Combination With Apatinib Mesylate Plus Short-course Chemotherapy for Advanced ESCC
NCT05738434 ·Status: RECRUITING ·Phase: PHASE2
-
Apatinib and Irinotecan Combination Treatment in Esophageal Squamous Cell Carcinoma
NCT02645864 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase III Study of Comparing Paclitaxel Plus 5-Fluorouracil Versus Cisplatin Plus 5-Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Carcinoma
NCT01591135 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Anlotinib Plus Sintilimab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
NCT04813406 ·Status: UNKNOWN ·Phase: NA