Clinical Analysis of HIPEC for T4 Colorectal Cancer After Surgery

Summary

This multicentric study aims to determine if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to prevent the development of peritoneal carcinomatosis in addition to the standard adjuvant systemic treatment after surgery.

Conditions

• Colorectal Neoplasms

Interventions

PROCEDURE

Surgery and HIPEC with Lobaplatin

The combination of surgery and HIPEC with Lobaplatin are performed in patients with colorectal cancer (T4N0-2M0).

PROCEDURE

Surgery without HIPEC

The patients with colorectal cancer (T4N0-2M0) are undergone a curative resection by laparoscopy or open approach.

Sponsors & Collaborators

• Second Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Zhujiang Hospital

  collaborator OTHER

• First Affiliated Hospital of Jinan University

  collaborator OTHER

• The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine

  collaborator OTHER

• Second Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• Guangzhou General Hospital of Guangzhou Military Command

  collaborator OTHER

• Tcm-integrated Cancer Center of Southern Medical University

  collaborator UNKNOWN

• Affiliated Cancer Hospital & Institute of Guangzhou Medical University

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  collaborator OTHER

• Guangdong Provincial Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Sixth Affiliated Hospital, Sun Yat-sen University

  lead OTHER

Principal Investigators

• MeiJin Huang, MD · Sixth Affiliated Hospital, Sun Yat-sen University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-08-01

Primary Completion

2021-08-01

Completion

2024-08-01