Trial Outcomes & Findings for A High School Program for Preventing Prescription Drug Misuse (NCT NCT03219190)
NCT ID: NCT03219190
Last Updated: 2026-03-10
Results Overview
This measure includes prescription drug misuse of sedatives, painkillers, and stimulants. Frequency of sedative, painkiller, and stimulant use without a doctor's prescription; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Prescription Drug Misuse (i.e., prescription drug use without a doctor's prescription); Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
COMPLETED
NA
1804 participants
Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported
2026-03-10
Participant Flow
Unit of analysis: Schools
Participant milestones
| Measure |
LST High School Hybrid
Provided with the prevention program, consisting of e-learning modules and classroom sessions.
LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
|
Treatment as Usual (Control)
Standard health education normally provided by the school
|
|---|---|---|
|
Overall Study
STARTED
|
1082 16
|
722 11
|
|
Overall Study
COMPLETED
|
731 10
|
504 9
|
|
Overall Study
NOT COMPLETED
|
351 6
|
218 2
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
A High School Program for Preventing Prescription Drug Misuse
Baseline characteristics by cohort
| Measure |
LST High School Hybrid
n=10 Schools
Provided with the prevention program, consisting of e-learning modules and classroom sessions.
LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
|
Treatment as Usual (Control)
n=9 Schools
Standard health education normally provided by the school
|
Total
n=19 Schools
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
15.2 years
n=68 Participants
|
15.2 years
n=69 Participants
|
15.2 years
n=137 Participants
|
|
Sex: Female, Male
Female
|
511 Participants
n=68 Participants
|
407 Participants
n=69 Participants
|
918 Participants
n=137 Participants
|
|
Sex: Female, Male
Male
|
220 Participants
n=68 Participants
|
97 Participants
n=69 Participants
|
317 Participants
n=137 Participants
|
|
Race/Ethnicity, Customized
White
|
567 Participants
n=68 Participants
|
438 Participants
n=69 Participants
|
1005 Participants
n=137 Participants
|
|
Race/Ethnicity, Customized
Non-White
|
164 Participants
n=68 Participants
|
66 Participants
n=69 Participants
|
230 Participants
n=137 Participants
|
|
Race/Ethnicity, Customized
Hispanic/Latino
|
110 Participants
n=68 Participants
|
48 Participants
n=69 Participants
|
158 Participants
n=137 Participants
|
PRIMARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes prescription drug misuse of sedatives, painkillers, and stimulants. Frequency of sedative, painkiller, and stimulant use without a doctor's prescription; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Prescription Drug Misuse (i.e., prescription drug use without a doctor's prescription); Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
Outcome measures
| Measure |
LST High School Hybrid
n=731 Participants
Provided with the prevention program, consisting of e-learning modules and classroom sessions.
LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
|
Treatment as Usual (Control)
n=504 Participants
Standard health education normally provided by the school
|
|---|---|---|
|
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription sedative misuse
|
1.06 score on a scale
Standard Error 0.02
|
1.12 score on a scale
Standard Error 0.03
|
|
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription painkiller misuse
|
1.11 score on a scale
Standard Error 0.03
|
1.13 score on a scale
Standard Error 0.04
|
|
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription stimulant misuse
|
1.09 score on a scale
Standard Error 0.02
|
1.11 score on a scale
Standard Error 0.04
|
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes alcohol use and alcohol intoxication. Frequency of alcohol use and alcohol intoxication; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Alcohol Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes tobacco use. Frequency of cigarette/tobacco use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Tobacco Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes marijuana use. Frequency of marijuana use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Marijuana Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes inhalant use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Inhalant Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes intentions to use substances: Intentions to use alcohol, get drunk, use tobacco, marijuana, and inhalants within the next year; measured on a 5-point scale from "Definitely Not" to "Definitely Will"; Unabbreviated scale title: Substance Use Intentions; Minimum value = 1; maximum value = 5; Higher scores are a worse outcome
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedThis measure includes perceived risk of harm associated with using prescription sedatives, painkillers, and stimulants when prescribed for someone else, measured on a 4-point scale from "No Risk" to "Great Risk;" also option for "Can't say, drug unfamiliar"; Unabbreviated scale title: Perceived Risk of Prescription Drug Misuse; Minimum value = 1; maximum value = 4; Higher scores are a better outcome
Outcome measures
| Measure |
LST High School Hybrid
n=731 Participants
Provided with the prevention program, consisting of e-learning modules and classroom sessions.
LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
|
Treatment as Usual (Control)
n=504 Participants
Standard health education normally provided by the school
|
|---|---|---|
|
Perceived Risk of Prescription Drug Misuse
Prescription sedatives, risk o harm
|
2.71 score on a scale
Standard Error 0.02
|
2.59 score on a scale
Standard Error 0.03
|
|
Perceived Risk of Prescription Drug Misuse
Prescription painkillers, risk o harm
|
2.75 score on a scale
Standard Error 0.02
|
2.58 score on a scale
Standard Error 0.03
|
|
Perceived Risk of Prescription Drug Misuse
Prescription stimulants, risk o harm
|
2.71 score on a scale
Standard Error 0.02
|
2.58 score on a scale
Standard Error 0.03
|
SECONDARY outcome
Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reportedSelf-regulation skills: the ability to control one's thoughts, feelings, and behaviors; Communication skills: the ability to communicate effectively; Media resistance skills: the ability to resist messages from the media; Anxiety management skills: the ability to recognize and manage physical manifestations of anxiety; Refusal skills: the ability to resist pressure to use substances; All response options on a 5-point scale from "Strongly Disagree" to "Strongly Agree; except Communication skills, with response options on a 5-point scale from "Never" to "Always"; Unabbreviated scale title: Life Skills; Minimum value = 1; maximum value = 5; Higher scores are a better outcome
Outcome measures
Outcome data not reported
Adverse Events
LST High School Hybrid
Treatment as Usual (Control)
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Christopher Williams
National Health Promotion Associates, Inc
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place