Trial Outcomes & Findings for A High School Program for Preventing Prescription Drug Misuse (NCT NCT03219190)

NCT ID: NCT03219190

Last Updated: 2026-03-10

Results Overview

This measure includes prescription drug misuse of sedatives, painkillers, and stimulants. Frequency of sedative, painkiller, and stimulant use without a doctor's prescription; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Prescription Drug Misuse (i.e., prescription drug use without a doctor's prescription); Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

1804 participants

Primary outcome timeframe

Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

Results posted on

2026-03-10

Participant Flow

Unit of analysis: Schools

Participant milestones

Participant milestones
Measure
LST High School Hybrid
Provided with the prevention program, consisting of e-learning modules and classroom sessions. LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
Treatment as Usual (Control)
Standard health education normally provided by the school
Overall Study
STARTED
1082 16
722 11
Overall Study
COMPLETED
731 10
504 9
Overall Study
NOT COMPLETED
351 6
218 2

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

A High School Program for Preventing Prescription Drug Misuse

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
LST High School Hybrid
n=10 Schools
Provided with the prevention program, consisting of e-learning modules and classroom sessions. LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
Treatment as Usual (Control)
n=9 Schools
Standard health education normally provided by the school
Total
n=19 Schools
Total of all reporting groups
Age, Continuous
15.2 years
n=68 Participants
15.2 years
n=69 Participants
15.2 years
n=137 Participants
Sex: Female, Male
Female
511 Participants
n=68 Participants
407 Participants
n=69 Participants
918 Participants
n=137 Participants
Sex: Female, Male
Male
220 Participants
n=68 Participants
97 Participants
n=69 Participants
317 Participants
n=137 Participants
Race/Ethnicity, Customized
White
567 Participants
n=68 Participants
438 Participants
n=69 Participants
1005 Participants
n=137 Participants
Race/Ethnicity, Customized
Non-White
164 Participants
n=68 Participants
66 Participants
n=69 Participants
230 Participants
n=137 Participants
Race/Ethnicity, Customized
Hispanic/Latino
110 Participants
n=68 Participants
48 Participants
n=69 Participants
158 Participants
n=137 Participants

PRIMARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes prescription drug misuse of sedatives, painkillers, and stimulants. Frequency of sedative, painkiller, and stimulant use without a doctor's prescription; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Prescription Drug Misuse (i.e., prescription drug use without a doctor's prescription); Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Outcome measures

Outcome measures
Measure
LST High School Hybrid
n=731 Participants
Provided with the prevention program, consisting of e-learning modules and classroom sessions. LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
Treatment as Usual (Control)
n=504 Participants
Standard health education normally provided by the school
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription sedative misuse
1.06 score on a scale
Standard Error 0.02
1.12 score on a scale
Standard Error 0.03
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription painkiller misuse
1.11 score on a scale
Standard Error 0.03
1.13 score on a scale
Standard Error 0.04
Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)
Prescription stimulant misuse
1.09 score on a scale
Standard Error 0.02
1.11 score on a scale
Standard Error 0.04

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes alcohol use and alcohol intoxication. Frequency of alcohol use and alcohol intoxication; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Alcohol Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes tobacco use. Frequency of cigarette/tobacco use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Tobacco Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes marijuana use. Frequency of marijuana use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Marijuana Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes inhalant use; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Inhalant Use; Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes intentions to use substances: Intentions to use alcohol, get drunk, use tobacco, marijuana, and inhalants within the next year; measured on a 5-point scale from "Definitely Not" to "Definitely Will"; Unabbreviated scale title: Substance Use Intentions; Minimum value = 1; maximum value = 5; Higher scores are a worse outcome

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

This measure includes perceived risk of harm associated with using prescription sedatives, painkillers, and stimulants when prescribed for someone else, measured on a 4-point scale from "No Risk" to "Great Risk;" also option for "Can't say, drug unfamiliar"; Unabbreviated scale title: Perceived Risk of Prescription Drug Misuse; Minimum value = 1; maximum value = 4; Higher scores are a better outcome

Outcome measures

Outcome measures
Measure
LST High School Hybrid
n=731 Participants
Provided with the prevention program, consisting of e-learning modules and classroom sessions. LST High School Hybrid: The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.
Treatment as Usual (Control)
n=504 Participants
Standard health education normally provided by the school
Perceived Risk of Prescription Drug Misuse
Prescription sedatives, risk o harm
2.71 score on a scale
Standard Error 0.02
2.59 score on a scale
Standard Error 0.03
Perceived Risk of Prescription Drug Misuse
Prescription painkillers, risk o harm
2.75 score on a scale
Standard Error 0.02
2.58 score on a scale
Standard Error 0.03
Perceived Risk of Prescription Drug Misuse
Prescription stimulants, risk o harm
2.71 score on a scale
Standard Error 0.02
2.58 score on a scale
Standard Error 0.03

SECONDARY outcome

Timeframe: Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

Self-regulation skills: the ability to control one's thoughts, feelings, and behaviors; Communication skills: the ability to communicate effectively; Media resistance skills: the ability to resist messages from the media; Anxiety management skills: the ability to recognize and manage physical manifestations of anxiety; Refusal skills: the ability to resist pressure to use substances; All response options on a 5-point scale from "Strongly Disagree" to "Strongly Agree; except Communication skills, with response options on a 5-point scale from "Never" to "Always"; Unabbreviated scale title: Life Skills; Minimum value = 1; maximum value = 5; Higher scores are a better outcome

Outcome measures

Outcome data not reported

Adverse Events

LST High School Hybrid

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Treatment as Usual (Control)

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Christopher Williams

National Health Promotion Associates, Inc

Phone: 914-421-2525

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place