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Neuroplasticity in Parkinson´s Disease After Training

NCT03213873 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 95

Last updated 2025-03-07

Study results available
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Summary

This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease. The main hypothesis is that highly challenging exercise will lead to greater gait and balance ability, increased levels of physical activity and an improved health related quality of life. The investigators further hypothesize that neuroplasticity changes will be seen in corresponding areas of the brain, neuropsychological changes on cognitive test measures, and that exercise will inhibit the degeneration of dopaminergic neurons in the brain through the mediation of neurotrophic factors.

Conditions

  • Parkinson Disease
  • Physical Activity
  • Gait Disorders, Neurologic
  • Neural Degeneration

Interventions

BEHAVIORAL

HiBalance

Intervention of highly challenging balance training for 10 weeks.

BEHAVIORAL

Speech and communication therapy

Intervention conducted by speech and language therapist for 10 weeks.

Sponsors & Collaborators

Principal Investigators

  • Maria Eriksdotter, Professor · Karolinska Institutet, NVS department

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-15
Primary Completion
2019-12-13
Completion
2019-12-23

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03213873 on ClinicalTrials.gov