Trial Outcomes & Findings for Social Media Based Peer-Led Intervention for HIV Prevention (NCT NCT03213366)
NCT ID: NCT03213366
Last Updated: 2019-11-06
Results Overview
This primary outcome is intention to use PrEP in the next month measured at baseline, 6 weeks, and 12 weeks. This was assessed with a yes/no question (dichotomous variable). However, this variable does not include anyone who reported PrEP use at either 6 or 12 weeks. This outcome will inform sample size calculations for a subsequent fully powered trial.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
152 participants
Primary outcome timeframe
baseline, 6 weeks, and 12 weeks
Results posted on
2019-11-06
Participant Flow
Unit of analysis: Peers
Participant milestones
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow-General Health Control Arm:
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Overall Study
STARTED
|
81 7
|
71 5
|
|
Overall Study
COMPLETED
|
72 5
|
67 5
|
|
Overall Study
NOT COMPLETED
|
9 2
|
4 0
|
Reasons for withdrawal
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow-General Health Control Arm:
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Overall Study
Lost to Follow-up
|
9
|
4
|
Baseline Characteristics
Social Media Based Peer-Led Intervention for HIV Prevention
Baseline characteristics by cohort
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=81 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=71 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
Total
n=152 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
24.28 years
STANDARD_DEVIATION 2.83 • n=99 Participants
|
23.32 years
STANDARD_DEVIATION 3.39 • n=107 Participants
|
23.84 years
STANDARD_DEVIATION 2.83 • n=206 Participants
|
|
Sex/Gender, Customized
Gender Identity · Male
|
68 Participants
n=99 Participants
|
64 Participants
n=107 Participants
|
132 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Gender Identity · Female/Transfemale
|
7 Participants
n=99 Participants
|
3 Participants
n=107 Participants
|
10 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Gender Identity · Transmale
|
1 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
1 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Gender Identity · Gender Non-conforming/Gender Non-Binary
|
2 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Gender Identity · Queer
|
3 Participants
n=99 Participants
|
4 Participants
n=107 Participants
|
7 Participants
n=206 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Latinx/Hispanic
|
26 Participants
n=99 Participants
|
47 Participants
n=107 Participants
|
73 Participants
n=206 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Non-Hispanic Black
|
55 Participants
n=99 Participants
|
24 Participants
n=107 Participants
|
79 Participants
n=206 Participants
|
|
Residence
Bronx
|
44 Participants
n=99 Participants
|
35 Participants
n=107 Participants
|
79 Participants
n=206 Participants
|
|
Residence
Brooklyn
|
18 Participants
n=99 Participants
|
14 Participants
n=107 Participants
|
32 Participants
n=206 Participants
|
|
Residence
Manhattan
|
16 Participants
n=99 Participants
|
13 Participants
n=107 Participants
|
29 Participants
n=206 Participants
|
|
Residence
Queens
|
2 Participants
n=99 Participants
|
8 Participants
n=107 Participants
|
10 Participants
n=206 Participants
|
|
Residence
Staten Island
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Sexual Identity
Gay/Homosexual
|
60 Participants
n=99 Participants
|
56 Participants
n=107 Participants
|
116 Participants
n=206 Participants
|
|
Sexual Identity
Queer
|
12 Participants
n=99 Participants
|
3 Participants
n=107 Participants
|
15 Participants
n=206 Participants
|
|
Sexual Identity
Bisexual
|
7 Participants
n=99 Participants
|
10 Participants
n=107 Participants
|
17 Participants
n=206 Participants
|
|
Sexual Identity
Heterosexual/Straight
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Sexual Identity
Other
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Education Level
High School or Less
|
36 Participants
n=99 Participants
|
27 Participants
n=107 Participants
|
63 Participants
n=206 Participants
|
|
Education Level
Some College
|
28 Participants
n=99 Participants
|
35 Participants
n=107 Participants
|
63 Participants
n=206 Participants
|
|
Education Level
College and Beyond
|
17 Participants
n=99 Participants
|
9 Participants
n=107 Participants
|
26 Participants
n=206 Participants
|
|
Employment
Full Time
|
24 Participants
n=99 Participants
|
29 Participants
n=107 Participants
|
53 Participants
n=206 Participants
|
|
Employment
Part Time
|
17 Participants
n=99 Participants
|
15 Participants
n=107 Participants
|
32 Participants
n=206 Participants
|
|
Employment
Unemployed
|
31 Participants
n=99 Participants
|
15 Participants
n=107 Participants
|
46 Participants
n=206 Participants
|
|
Employment
Disable
|
3 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
5 Participants
n=206 Participants
|
|
Employment
Student
|
12 Participants
n=99 Participants
|
13 Participants
n=107 Participants
|
25 Participants
n=206 Participants
|
|
Income
None
|
12 Participants
n=99 Participants
|
14 Participants
n=107 Participants
|
26 Participants
n=206 Participants
|
|
Income
Less than $10,000
|
26 Participants
n=99 Participants
|
15 Participants
n=107 Participants
|
41 Participants
n=206 Participants
|
|
Income
$10,000-$19,999
|
11 Participants
n=99 Participants
|
10 Participants
n=107 Participants
|
21 Participants
n=206 Participants
|
|
Income
$20,000-$29,999
|
13 Participants
n=99 Participants
|
6 Participants
n=107 Participants
|
19 Participants
n=206 Participants
|
|
Income
$30,000-$39,999
|
11 Participants
n=99 Participants
|
16 Participants
n=107 Participants
|
27 Participants
n=206 Participants
|
|
Income
$40,000-more
|
8 Participants
n=99 Participants
|
10 Participants
n=107 Participants
|
18 Participants
n=206 Participants
|
|
Living Situation
Don't have a place to live
|
4 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
6 Participants
n=206 Participants
|
|
Living Situation
Temporary Living Situation
|
15 Participants
n=99 Participants
|
7 Participants
n=107 Participants
|
22 Participants
n=206 Participants
|
|
Living Situation
Parents/Family
|
29 Participants
n=99 Participants
|
36 Participants
n=107 Participants
|
65 Participants
n=206 Participants
|
|
Living Situation
Partner/Boyfriend/Husband
|
2 Participants
n=99 Participants
|
7 Participants
n=107 Participants
|
9 Participants
n=206 Participants
|
|
Living Situation
Roomates
|
20 Participants
n=99 Participants
|
14 Participants
n=107 Participants
|
34 Participants
n=206 Participants
|
|
Living Situation
Alone
|
11 Participants
n=99 Participants
|
4 Participants
n=107 Participants
|
15 Participants
n=206 Participants
|
|
Living Situation
Wife/Females Partner/Girlfriend
|
0 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
1 Participants
n=206 Participants
|
|
Health Insurance
Yes
|
61 Participants
n=99 Participants
|
59 Participants
n=107 Participants
|
120 Participants
n=206 Participants
|
|
Health Insurance
No
|
18 Participants
n=99 Participants
|
10 Participants
n=107 Participants
|
28 Participants
n=206 Participants
|
|
Health Insurance
I don't kno
|
2 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
4 Participants
n=206 Participants
|
PRIMARY outcome
Timeframe: baseline, 6 weeks, and 12 weeksPopulation: Each of the rows indicates the number of participants who indicated intending to use PrEP at each time point (Baseline vs. 6 weeks vs. 12 weeks).
This primary outcome is intention to use PrEP in the next month measured at baseline, 6 weeks, and 12 weeks. This was assessed with a yes/no question (dichotomous variable). However, this variable does not include anyone who reported PrEP use at either 6 or 12 weeks. This outcome will inform sample size calculations for a subsequent fully powered trial.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Number of Participants Intending to Start Using PrEP Over Time
Baseline · Yes
|
32 Participants
|
34 Participants
|
|
Number of Participants Intending to Start Using PrEP Over Time
Baseline · No
|
33 Participants
|
29 Participants
|
|
Number of Participants Intending to Start Using PrEP Over Time
6 Weeks · Yes
|
23 Participants
|
27 Participants
|
|
Number of Participants Intending to Start Using PrEP Over Time
6 Weeks · No
|
42 Participants
|
36 Participants
|
|
Number of Participants Intending to Start Using PrEP Over Time
12 Weeks · Yes
|
27 Participants
|
32 Participants
|
|
Number of Participants Intending to Start Using PrEP Over Time
12 Weeks · No
|
38 Participants
|
31 Participants
|
PRIMARY outcome
Timeframe: at baseline, 6 weeks, and 12 weeksThis outcome is the number of participants who self-report using PrEP at baseline, 6 weeks, or 12 weeks. This was measure by a yes/no question asking if the participant currently uses PrEP (dichotomous variable).
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Number of Participants Using PrEP Over Time
Baseline · Yes
|
13 Participants
|
11 Participants
|
|
Number of Participants Using PrEP Over Time
Baseline · No
|
52 Participants
|
52 Participants
|
|
Number of Participants Using PrEP Over Time
6 weeks · Yes
|
17 Participants
|
11 Participants
|
|
Number of Participants Using PrEP Over Time
6 weeks · No
|
48 Participants
|
52 Participants
|
|
Number of Participants Using PrEP Over Time
12 weeks · Yes
|
14 Participants
|
13 Participants
|
|
Number of Participants Using PrEP Over Time
12 weeks · No
|
51 Participants
|
50 Participants
|
SECONDARY outcome
Timeframe: at baseline, 6 weeks, and 12 weeksSelf-reported PrEP related knowledge. Participants were asked two questions about PrEP knowledge. For each question, they got one point if the answer was correct. Scale range from 0-2. The score were added and the average of the sum was reported. The higher the score, the higher the knowledge of PrEP.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Change in PrEP Knowledge
Baseline
|
1.86 score on a scale
Standard Deviation 0.43
|
1.7 score on a scale
Standard Deviation 0.59
|
|
Change in PrEP Knowledge
6 Weeks
|
1.86 score on a scale
Standard Deviation 0.39
|
1.83 score on a scale
Standard Deviation 0.46
|
|
Change in PrEP Knowledge
12 Weeks
|
1.83 score on a scale
Standard Deviation 0.49
|
1.73 score on a scale
Standard Deviation 0.55
|
SECONDARY outcome
Timeframe: baseline, 6 weeks, 12 weeksPopulation: T
Awareness about PrEP. PrEP awareness was measured with one question, scored 1 to 5. The mean for each arm was calculated at each time point. The higher the score, the higher the level of awareness about PrEP.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
PrEP Awareness
Baseline
|
4.14 score on a scale
Standard Deviation 0.95
|
4.02 score on a scale
Standard Deviation 0.88
|
|
PrEP Awareness
6 Weeks
|
4.29 score on a scale
Standard Deviation 0.96
|
4.13 score on a scale
Standard Deviation 0.91
|
|
PrEP Awareness
12 Weeks
|
4.52 score on a scale
Standard Deviation 0.69
|
4.19 score on a scale
Standard Deviation 0.91
|
SECONDARY outcome
Timeframe: baseline, 6 weeks, 12 weeksAny stigma the participant might have about PrEP or those who use PrEP To measure PrEP Stigma we asked 3 questions, using a Likert scale (from 1-4; 1= Strongly Disagree, 4=Strongly Agree). The scores were summed for each participant. The scores range from 1-12, with higher scores indicating higher levels of PrEP Stigma. The higher the score, the higher the level of PrEP stigma.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=69 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
PrEP Stigma
Baseline
|
6.25 score on a scale
Standard Deviation 2.21
|
6.78 score on a scale
Standard Deviation 2.39
|
|
PrEP Stigma
6 Weeks
|
5.40 score on a scale
Standard Deviation 2.55
|
6.24 score on a scale
Standard Deviation 2.87
|
|
PrEP Stigma
12 Weeks
|
5.12 score on a scale
Standard Deviation 2.34
|
6.0 score on a scale
Standard Deviation 2.53
|
SECONDARY outcome
Timeframe: baseline, 6 weeks, 12 weeksDiscussion of PrEP with friends, partners, or family. Communication about PrEP was measured with 2 questions, using a Likert scale ( from 1-5;1=Not at all, 5= Extremely). The scores of the 2 questions were summed for each participant. The scores range from 1-10, with higher the score indicating higher the level of communication about PrEP (i.e. higher scores indicates participants communicating more about PrEP).
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Communication About PrEP
6 Weeks
|
9.14 score on a scale
Standard Deviation 1.47
|
8.60 score on a scale
Standard Deviation 1.85
|
|
Communication About PrEP
12 Weeks
|
8.94 score on a scale
Standard Deviation 1.81
|
8.32 score on a scale
Standard Deviation 2.14
|
|
Communication About PrEP
Baseline
|
8.42 score on a scale
Standard Deviation 2.38
|
8.24 score on a scale
Standard Deviation 2.29
|
SECONDARY outcome
Timeframe: baseline, 6 weeks, 12 weeksAny Barriers to PrEP uptake. To measure barriers to PrEP uptake, 7 items were used. Each item was measured using a likert scale ( from 1-4; 1=Strongly Disagree, 4= Strongly Agree). The scores of each question were summed for each participant (scale scores ranged 1-28, with higher scores indicating higher levels of PrEP Barriers). The higher the score, the higher the number of PrEP Barriers.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
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|---|---|---|
|
PrEP Barriers
Baseline
|
17.80 score on a scale
Standard Deviation 4.28
|
18.73 score on a scale
Standard Deviation 4.6
|
|
PrEP Barriers
6 Weeks
|
17.11 score on a scale
Standard Deviation 5.17
|
18.76 score on a scale
Standard Deviation 5.22
|
|
PrEP Barriers
12 Weeks
|
16.55 score on a scale
Standard Deviation 4.92
|
17.84 score on a scale
Standard Deviation 5.20
|
SECONDARY outcome
Timeframe: at baseline, 6 weeks, and 12 weeksSelf-reported answer to questions about self-efficacy of using PrEP. There were two questions to measure self-efficacy of PrEP using a Likert scale (ranging from 1-5; 1=Not at all, 5=Extremely). The scores from both questions were summed for each participant. The scale range from 1-10 with higher scores indicating higher the levels of PrEP self-efficacy.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=65 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=63 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
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|---|---|---|
|
Self-efficacy About Using PrEP
Baseline
|
8.26 score on a scale
Standard Deviation 2.39
|
8.19 score on a scale
Standard Deviation 2.35
|
|
Self-efficacy About Using PrEP
6 Weeks
|
8.88 score on a scale
Standard Deviation 1.72
|
8.49 score on a scale
Standard Deviation 1.86
|
|
Self-efficacy About Using PrEP
12 Weeks
|
8.75 score on a scale
Standard Deviation 1.97
|
8.13 score on a scale
Standard Deviation 2.35
|
OTHER_PRE_SPECIFIED outcome
Timeframe: at baseline, 6 weeks, and 12 weeksPopulation: Each row indicates when the participant who responded to the survey at baseline, 6 weeks, and 12 weeks.
Self-reported HIV testing at baseline, 6 weeks, and 12 weeks.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=81 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=71 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Number of Participants With Self-reported HIV Testing
Baseline · 1 month
|
33 Participants
|
22 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · 3 months or less
|
31 Participants
|
19 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · 4 to 6 months
|
9 Participants
|
15 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · 7 to 12 months
|
0 Participants
|
7 Participants
|
|
Number of Participants With Self-reported HIV Testing
Baseline · 3 months or less
|
29 Participants
|
20 Participants
|
|
Number of Participants With Self-reported HIV Testing
Baseline · 4 to 6 months
|
10 Participants
|
16 Participants
|
|
Number of Participants With Self-reported HIV Testing
Baseline · 7 to 12 months
|
6 Participants
|
7 Participants
|
|
Number of Participants With Self-reported HIV Testing
Baseline · More than 12 months
|
1 Participants
|
2 Participants
|
|
Number of Participants With Self-reported HIV Testing
Baseline · I have never been tested for STI
|
2 Participants
|
4 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · 1 month
|
24 Participants
|
20 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · 3 months or less
|
26 Participants
|
23 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · 4 to 6 months
|
11 Participants
|
13 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · 7 to 12 months
|
1 Participants
|
6 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · More than 12 months
|
5 Participants
|
3 Participants
|
|
Number of Participants With Self-reported HIV Testing
6 Weeks · I have never been tested for STI
|
2 Participants
|
1 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · 1 month
|
26 Participants
|
18 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · More than 12 months
|
4 Participants
|
3 Participants
|
|
Number of Participants With Self-reported HIV Testing
12 Weeks · I have never been tested for STI
|
1 Participants
|
3 Participants
|
OTHER_PRE_SPECIFIED outcome
Timeframe: at baseline, 6 weeks, and 12 weeksPopulation: Each row has the number of participants who access healthcare at each time point in the "yes" category, and the number of people who did not access healthcare in the "no" category. (Baseline vs. 6 weeks vs. 12 weeks).
Self-reported information about health care access (i.e. going to a medical appointment).
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=81 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=71 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Number of Participants With Self-reported Linkage-to-Care
Baseline- Visit in the past 12 months · Yes
|
61 Participants
|
64 Participants
|
|
Number of Participants With Self-reported Linkage-to-Care
Baseline- Visit in the past 12 months · No
|
20 Participants
|
7 Participants
|
|
Number of Participants With Self-reported Linkage-to-Care
6 Weeks- Visit in the past 6 weeks · Yes
|
40 Participants
|
41 Participants
|
|
Number of Participants With Self-reported Linkage-to-Care
6 Weeks- Visit in the past 6 weeks · No
|
29 Participants
|
25 Participants
|
|
Number of Participants With Self-reported Linkage-to-Care
12 Weeks- Visit in the past 12 weeks · Yes
|
45 Participants
|
33 Participants
|
|
Number of Participants With Self-reported Linkage-to-Care
12 Weeks- Visit in the past 12 weeks · No
|
26 Participants
|
32 Participants
|
OTHER_PRE_SPECIFIED outcome
Timeframe: at baseline and 6 weeksPopulation: The total number of participants who completed baseline study was 81 for e-prep and 71 for control. The analysis for 6 weeks included only the people who completed the survey at each that time period.
The scale measure the level of trust the Participant had on the Peer's online post. Trust in the Peer Leader was measured using 4 questions, each scored from 1-7 (1=Strongly Disagree, 7=Strongly Agree). The score for the 4 questions was summed for each participant. The score ranged from 1-28 with higher scores indicating a higher level of trust the participant had in their Peer Leader.
Outcome measures
| Measure |
E-PrEP- Peer-Led Intervention About PrEP
n=81 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: The E-PrEP campaign focused on delivering information about PrEP. The materials were composed of 6 weeks of publicly available PrEP educations materials selected by peer advisors prior to the intervention (i.e. information on how to talk to your doctor about PrEP, where to get PrEP, side effects, etc.). The materials mapped out onto Diffusion of Innovation (DOI) and Information, Motivation, Behavior (IMB) domains. Peer leaders framed the E-PrEP materials in their own words when posting the materials to their online private group.
|
BxNow- General Health Control Arm
n=71 Participants
We recruited Peer Leaders over a 5-week period and then randomly assigned them to the 2 arms. Peer Leaders were blinded to their study condition. Peer leaders recruited study participants via their existing online social networks to complete an online eligibility screener and baseline survey. Study participants were then directed to join a private online group, facilitated and moderated by the peer leader who had recruited them.
Content: BxNow focused on a broad range of health topics prioritized by the peer leaders assigned to this arm, but did not include any contents about HIV or PrEP (i.e. depression, anxiety, suicide, intimate partner violence, drug use, awareness of sexually transmitted infections). BxNow was attention matched to the E-PrEP intervention timeline (6 weeks of materials) for both time and day of posts and frequency of posts. As with E-PrEP, standardized BxNow contents were delivered by peer leaders, framed using their own words.
|
|---|---|---|
|
Trust in the Peer by Participant
6 Weeks
|
16.06 score on a scale
Standard Deviation 4.48
|
15.71 score on a scale
Standard Deviation 4.28
|
|
Trust in the Peer by Participant
Baseline
|
16.4 score on a scale
Standard Deviation 4.15
|
14.32 score on a scale
Standard Deviation 4.27
|
Adverse Events
E-PrEP- Peer-Led Intervention About PrEP
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
BxNow - General Health Campaign
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place