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Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

NCT03202823 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2026-02-09

No results posted yet for this study

Summary

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Conditions

  • Carotid Stenosis

Interventions

PROCEDURE

blood samples

3 tubes (5 ml volume) collected during surgery

PROCEDURE

recover samples of atheromatous plaque

a carotid sample collected during surgery

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Dijon

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-04-13
Primary Completion
2020-12-11
Completion
2020-12-11

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03202823 on ClinicalTrials.gov