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Chronic Hepatitis B Virus Infection in Zambia

NCT03158818 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 326

Last updated 2025-06-10

No results posted yet for this study

Summary

Chronic hepatitis B virus infection is a common condition in Zambia. Among Zambian blood donors, up to 8% are chronically infected with HBV. Despite the burden, awareness of HBV is low in Zambia and the Ministry of Health is in early stages of development of guidelines for HBV screening, treatment, and prevention. The purpose of this clinical cohort study is to characterize the clinical features of chronic HBV infection at UTH and describe treatment and care outcomes. The investigators will enroll 500 adults and follow the cohort for up to 5 years to assess short and long-term viral, serologic, and liver outcomes such as cirrhosis and liver cancer.

Conditions

Interventions

OTHER

Standard of care

Routine standard of care per Ministry of Health protocol, including blood draws and examinations.

Sponsors & Collaborators

  • Tropical Gastroenterology and Nutrition Group

    collaborator UNKNOWN

  • Centre for Infectious Disease Research in Zambia

    collaborator OTHER

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Michael J Vinikoor, MD · University of Alabama at Birmingham

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-23
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • Zambia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03158818 on ClinicalTrials.gov