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A New Model of Acute Febrile Disease

NCT03158363 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2019-02-22

No results posted yet for this study

Summary

The investigators want to establish a new model of acute febrile disease by mimicking the conditions seen in hospitalized patients in regards to inflammation, immobilisation and fasting. In this new model of disease, healthy young adults will be given lipopolysaccharide (LPS) to induce endotoxemia and inflammation/fever and then fast and bedrest for 36 hours. Glucose, fat and protein metabolism will be investigated using clamp technique and tracer methodology together with intracellular signalling pathway activation in muscle and fat biopsies. This new model of disease will later be used in another study to investigate different protein supplement´s effect on muscle waste during acute febrile disease.

Conditions

  • Immobilization, Tonic
  • Fasting
  • Endotoxemia
  • Metabolism

Interventions

OTHER

LPS, 36 hour immobilization and fast

LPS endotoxin is administered on study day 1 and immobilization and fast continue throughout study day 1 and 2.

Sponsors & Collaborators

  • Arla

    collaborator UNKNOWN

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Niels Moeller, Professor · Institute for Clinical Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2017-08-31
Completion
2017-08-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03158363 on ClinicalTrials.gov