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Pilot of Zinc Acetate to Improve Chronic Cough

NCT03135522 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2021-01-20

Study results available
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Summary

The Pilot of Zinc Acetate to Improve Chronic Cough (ZICO) is a study of 36 patients with chronic refractory cough that will be used to (1) assess if zinc acetate (150 mg/day) will improve patient reported measures of cough, (2) to establish if treatment with zinc acetate is well tolerated, and (3) to determine if the trial logistics are feasible.

Conditions

Interventions

DRUG

Zinc Acetate 50 Mg Oral Capsule

* Day 0 (randomization) to day 3 Zinc acetate 50 mg per day (one capsule) * Day 4 to day 7 If well tolerated: Zinc acetate 100 mg per day (two capsules) * Day 8 to V5 (6 weeks) If well tolerated: Zinc acetate 150 mg per day (three capsules)

DRUG

Placebo oral capsule

* Day 0 (randomization) to day 3 Placebo (one capsule per day) * Day 4 to day 7 If well tolerated: placebo (two capsules per day) * Day 8 to V5 (6 weeks) If well tolerated: placebo (three capsules per day)

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • American Lung Association

    collaborator OTHER

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Robert Wise, MD · Johns Hopkins University

  • Janet Holbrook, PhD · Johns Hopkins University Bloomberg School of Public Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-14
Primary Completion
2019-12-11
Completion
2019-12-11
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03135522 on ClinicalTrials.gov