MedTrace Logo

TCA Cycle in the Dentate in Friedreich's Ataxia

NCT03122925 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-03-27

No results posted yet for this study

Summary

OBJECTIVE: To measure the tricarboxylic acid (TCA) cycle rate in the dentate nucleus in a group of control subjects and subjects with Friedreich's Ataxia (FRDA).

HYPOTHESIS: The TCA cycle rate will be lower in FRDA subjects than in controls APPROACH: The investigators will infuse carbon-13 (13C) labeled glucose and measure the rate of 13C label incorporation from glucose to glutamate in the brain using in vivo magnetic resonance spectroscopy.

Conditions

  • Friedreich Ataxia

Interventions

DEVICE

MR

MR

Sponsors & Collaborators

Principal Investigators

  • Pierre-Gilles Henry, PhD · University of Minnesota

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-08-29
Primary Completion
2023-01-11
Completion
2023-01-11
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03122925 on ClinicalTrials.gov