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Evaluating the Role of Neuroinflammation in Low Back Pain

NCT03106740 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-02-11

Study results available
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Summary

In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline use for low back pain treatment will also be evaluated by observing whether short-term minocycline administration will reduce neuroinflammation and low back pain symptoms.

Conditions

  • Low Back Pain
  • Back Pain With Radiation
  • Back Pain Without Radiation
  • Back Pain Lower Back Chronic
  • Back Ache
  • Pain, Chronic

Interventions

DRUG

Minocycline Hydrochloride 100mg Capsule

Minocycline 100mg will be administered by mouth daily for 2 weeks

DIAGNOSTIC_TEST

Magnetic Resonance-Positron Emission Tomography Imaging

Up to 15 millicuries of \[11C\]PBR28 will be administered to each subject at each imaging visit, for a maximum of 2 imaging visits.

OTHER

Placebo Capsule

1 Placebo Capsule (compounded with lactose powder) will be administered by mouth daily for 2 weeks

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Marco Loggia

    lead OTHER

Principal Investigators

  • Marco L Loggia, PhD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-10
Primary Completion
2024-04-30
Completion
2024-04-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03106740 on ClinicalTrials.gov