Efficacy and Safety of Sorafenib as Adjuvant and Latter Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma

Summary

Radiofrequency ablation is a popular treatment for recurrent hepatocellular carcinoma (HCC),but still has a higher recurrence. Sorafenib as neo-adjuvant therapy in combination of RFA was not reported yet. There's a theoretical advantage of this combination. Hence in this study the efficacy and safety of pre-administrative Sorafenib and Latter radiofrequency ablation (RFA) in Recurrent HCC will be tested in a multicenter prospective cohort study.

Conditions

• HCC

Interventions

PROCEDURE

RFA

for eligible cases, radiofrequency ablation will be given only.

DRUG

Sorafenib

for eligible cases, combination treatment with RFA and Sorafenib will be given.That is sorafenib for 2 week,then radiofrequency ablation

Sponsors & Collaborators

• Chengdu PLA General Hospital

  collaborator OTHER

• Sichuan Provincial People's Hospital

  collaborator OTHER

• Sichuan Cancer Hospital and Research Institute

  collaborator OTHER

• Hunan Cancer Hospital

  collaborator OTHER

• Cancer Hospital of Guangxi Medical University

  collaborator OTHER

• The First People's Hospital of Yunnan

  collaborator OTHER

• Yunnan Cancer Hospital

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• Xinqiao Hospital of Chongqing

  collaborator OTHER

• The Second Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• Henan Cancer Hospital

  collaborator OTHER_GOV

• First Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Southwest Hospital, China

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-05-04

Primary Completion

2018-12-30

Completion

2018-12-31

Countries

• China

Study Locations