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Sonothrombolysis in Patients With STEMI

NCT03092089 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2021-06-09

Study results available
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Summary

This study evaluates what effect sonothrombolysis may have on spontaneous reperfusion, microvascular obstruction, left ventricular function and infarct size in patients presenting with their first ST-segment Elevation Myocardial Infarction.

Conditions

  • ST-segment Elevation Myocardial Infarction

Interventions

DRUG

Definity, (Lipid Microspheres) Intravenous Suspension

Sonothrombolysis (High Impulse therapeutic ultrasound with infusion of ultrasound contrast agent Definity) will be applied before and after standard of care reperfusion therapy with PPCI

DEVICE

Myocardial Contrast Echocardiography

Myocardial contrast echocardiography will be applied before standard of care reperfusion therapy as well as prior to discharge and at 3 month follow up

PROCEDURE

Repurfusion therapy with PPCI

Patients will receive reperfusion therapy with PPCI as standard of care

Sponsors & Collaborators

  • Alberta Health services

    collaborator OTHER

  • University of Alberta

    collaborator OTHER

  • Harald Becher

    lead OTHER

Principal Investigators

  • Harald Becher · University of Alberta

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-15
Primary Completion
2019-10-03
Completion
2019-10-03
FDA Drug
Yes

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03092089 on ClinicalTrials.gov