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MRI of Neonate With HIE Before and During the Moderate Hypothermia

NCT03079492 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2017-03-14

No results posted yet for this study

Summary

Moderate hypothermia has been demonstrated to be the effective treatment for neonates with hypoxic-ischemic encephalopathy (HIE). However, few studies reveal the actual alterations in physiological parameters (i.e. brain temperature and cerebral blood flow) of neonates undergoing cooling, especially for HIE lesions. Therefore, this project aims to utilize the magnetic resonance imaging (MRI), i.e. MR thermal imaging and phase contrast MRI to measure the changes of these parameters before and during hypothermia; and then make comparisons with the routine nasopharyngeal and rectal temperature. All these would provide in vivo quantitative data for therapeutic evaluation and promote the optimization.

Conditions

  • Hypoxic-Ischemic Encephalopathy

Interventions

DEVICE

Magnetic resonance imaging

Magnetic resonance imaging will be used to estimate brain temperature and cerebral blood flow

Sponsors & Collaborators

  • First Affiliated Hospital Xi'an Jiaotong University

    lead OTHER

Principal Investigators

  • Chao Jin, Phd · First Affiliated Hospital Xi'an Jiaotong University

Eligibility

Min Age
6 Hours
Max Age
4 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2019-05-31
Completion
2020-05-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03079492 on ClinicalTrials.gov