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The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

NCT03079414 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-06-15

No results posted yet for this study

Summary

Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.

Conditions

Interventions

PROCEDURE

Invasive Electrophysiology Study

Invasive electrophysiology studies will be performed using four catheters placed in the right ventricular apex, the coronary sinus, the His bundle region, and the high right atrium. Standard induction protocols for supraventricular and ventricular arrhythmias will be utilized in the absence and presence of isoproterenol. Long-short ventricular extra-stimuli will also be delivered to screen for bundle branch reentrant ventricular tachycardia. The study is considered observational as the participating sites perform electrophysiology studies in this patient population as part of standard clinical care.

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Western University, Canada

    lead OTHER

Principal Investigators

  • Jason D Roberts, MD MAS · Western University

  • Andrew D Krahn, MD · University of British Columbia

  • Melvin M Scheinman, MD · University of California, San Francisco

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2025-06-01
Completion
2025-06-01

Countries

  • United States
  • Canada
  • Israel

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03079414 on ClinicalTrials.gov