Risk Factors of SUDEP

Summary

Numerous studies over the past decade have shown without any doubt that there is a higher mortality risk in patients with epilepsy than in the general population. The cause of death may be related to the cause of epilepsy, being directly related to a seizure (status epilepticus or sudden unexpected death in epilepsy; SUDEP), a consequence of seizures (accidents, etc), other associated pathologies (cancer, cardiovascular disease, ischemic heart disease, pneumonia, etc) or an associated disorder (depression or suicide). A SUDEP is defined as a sudden, non-traumatic, unexpected death in a patient with epilepsy, not necessarily in the presence of witnesses, that is not due to drowning, with or without evidence of a seizure, excluding documented status epilepticus and in which a post-mortem autopsy reveals no anatomical or toxicological cause of death. Little is known about SUDEP and its mechanisms and risk factors.

This epidemiological study is based on the RSME. The Main objective of this study to identify risk factors of SUDEP, in particular night-time supervision and the risks associated with anti-epileptic drugs including compliance and drug interactions.

Conditions

• Epilepsy

Interventions

OTHER

Interview with a psychologist and self-reported questionnaires

The family members or patients who decide to participate in the study will be asked to complete an interview with a psychologist (semistructured interview, standard form, questionnaires) and self-reported questionnaires

Sponsors & Collaborators

• French Foundation for Epilepsy Research (FFRE)

  collaborator UNKNOWN

• The French League Against Epilepsy (LFCE)

  collaborator UNKNOWN

• University Hospital, Bordeaux

  collaborator OTHER

• University Hospital, Lille

  collaborator OTHER

• Hospices Civils de Lyon

  collaborator OTHER

• University Hospital, Marseille

  collaborator OTHER

• Central Hospital, Nancy, France

  collaborator OTHER

• Paris AP-HP (La Pitié, St Anne, Necker, Robert Debré)

  collaborator UNKNOWN

• Rennes University Hospital

  collaborator OTHER

• University Hospital, Strasbourg, France

  collaborator OTHER

• ToulouseUniversity Hospital

  collaborator UNKNOWN

• University Hospital, Montpellier

  lead OTHER

Principal Investigators

• Marie-Christine Picot, MD, PhD · University Hospital, Montpellier

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-07-01

Primary Completion

2017-12-31

Completion

2018-07-31

Countries

• France

Study Locations