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The Role of Thyroid Status in Regulating Brown Adipose Tissue Activity, White Adipose Tissue Partitioning and Resting Energy Expenditure

NCT03064542 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2023-05-25

No results posted yet for this study

Summary

To determine how thyroid status regulates the relationship between brown adipose tissue (BAT) volume/activity, white adipose tissue (WAT) partitioning and basal metabolic rate (BMR) in hyperthyroid patients transitioning to euthyroidism via antithyroid drugs.

To compare euthyroid outcomes (BAT, WAT, BMR, body composition, body weight and insulin resistance) achieved by hypothalamus-pituitary-thyroid (HPT) set point vs. normal ranges of plasma free thyroxine 4 (FT4) and throxine stimulating hormone (TSH).

Conditions

  • Hyperthyroidism

Interventions

DRUG

carbimazole (CMZ) or thiamazole (TMZ)

CMZ or TMZ will be used to treat the hyperthyroidism till the FT4/TSH is in normal range.

Sponsors & Collaborators

  • Agency for Science, Technology and Research

    collaborator OTHER

  • Singapore Institute of Food and Biotechnology Innovation

    lead OTHER_GOV

Eligibility

Min Age
21 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-13
Primary Completion
2023-05-19
Completion
2023-05-19

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03064542 on ClinicalTrials.gov