MedTrace Logo

Vascular Health With Immobilization and Exercise Training

NCT03054376 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2022-11-02

No results posted yet for this study

Summary

The study includes healthy young habitually active subjects. All subjects are subjected to two weeks of immobilization of one leg followed by four weeks of training of both legs. The subjects are randomized to either one-leg training of the non-immobilized leg during the two-week immobilization period or to no training of the non-immobilized leg during the immobilization period. Measures include skeletal muscle morphology, markers of angiogenesis and apoptosis, muscle metabolic markers, vascular function, vascular proteins and performance.

Conditions

  • Immobilization, Tonic
  • Physical Activity

Interventions

OTHER

Immobilization

Full length cast of one leg R/L randomized

OTHER

Training with non immobilized leg

Exercise training will be conducted with the non-immobilized leg during the immobilization period of two weeks

OTHER

Exercise training with both legs

Exercise training will be conducted regularly on a cycle ergometer during a four week period

Sponsors & Collaborators

  • Johannes Gutenberg University Mainz

    collaborator OTHER

  • University of Leeds

    collaborator OTHER

  • Liverpool John Moores University

    collaborator OTHER

  • Radboud University Medical Center

    collaborator OTHER

  • University of Copenhagen

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-15
Primary Completion
2022-10-20
Completion
2022-10-20

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03054376 on ClinicalTrials.gov