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Brain Networks in Dystonia

NCT03042962 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 141

Last updated 2025-12-08

No results posted yet for this study

Summary

To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia. The goal of this study is to dissect the pathophysiological mechanisms underlying this clinical phenomenon using multi-level brain network analysis in patients with focal dystonia.

Conditions

  • Spasmodic Dysphonia
  • Singer's Dystonia
  • Writer's Cramp
  • Musician's Focal Hand Dystonia
  • Craniofacial Dystonia
  • Blepharospasm Oromandibular Dystonia

Interventions

OTHER

MRI

Functional and structural MRI of the brain will be conducted to identify disorder specific neural markers

PROCEDURE

Blood draw

Blood samples will be collected, the DNA will be extracted and banked for genetic studies

Sponsors & Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)

    collaborator NIH

  • Massachusetts Eye and Ear Infirmary

    lead OTHER

Principal Investigators

  • Kristina Simonyan, MD, PhD · Massachusetts Eye and Ear Infirmary

Eligibility

Min Age
21 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03042962 on ClinicalTrials.gov