Trial Outcomes & Findings for A New and Innovative Method for CO2 Removal in Anesthetic Circuits (NCT NCT03014336)
NCT ID: NCT03014336
Last Updated: 2026-02-23
Results Overview
The mean concentration of carbon dioxide during the expiratory cycle, measured as a percentage (%), measured over the course of the surgical procedure.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
286 participants
Primary outcome timeframe
From the start to the end of the intra-operative period for each participant
Results posted on
2026-02-23
Participant Flow
Participant milestones
| Measure |
Control
Patients receive standard care with a standard CO2 absorber and agree to include their data in the study.
|
Memsorb
Patients agree to receive standard care but using memsorb, the new CO2 filter evaluated in this study.
memsorb: memsorb is a CO2 filter replacing current chemical CO2 absorbers
|
|---|---|---|
|
Overall Study
STARTED
|
111
|
175
|
|
Overall Study
COMPLETED
|
111
|
175
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Control
n=111 Participants
Patients receive standard care with a standard CO2 absorber and agree to include their data in the study.
|
Memsorb
n=175 Participants
Patients agree to receive standard care but using memsorb, the new CO2 filter evaluated in this study.
memsorb: memsorb is a CO2 filter replacing current chemical CO2 absorbers
|
Total
n=286 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Customized
≥ 18 years
|
111 participants
n=111 Participants
|
175 participants
n=175 Participants
|
286 participants
n=286 Participants
|
|
Sex: Female, Male
Female
|
55 Participants
n=111 Participants
|
87 Participants
n=175 Participants
|
142 Participants
n=286 Participants
|
|
Sex: Female, Male
Male
|
56 Participants
n=111 Participants
|
88 Participants
n=175 Participants
|
144 Participants
n=286 Participants
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
PRIMARY outcome
Timeframe: From the start to the end of the intra-operative period for each participantPopulation: Surgical participants.
The mean concentration of carbon dioxide during the expiratory cycle, measured as a percentage (%), measured over the course of the surgical procedure.
Outcome measures
| Measure |
Memsorb Group - ExpDes
Expired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - ExpSEVO
Inspired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - inspDes
Inspired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - inspSEVO
Inspired concentration of sevoflurane in the memsorb surgical group.
|
Control
n=100 Participants
Patients receive standard care with a standard CO2 absorber and agree to include their data in the study.
|
Memsorb
n=154 Participants
Patients agree to receive standard care but using memsorb, the new CO2 filter evaluated in this study.
memsorb: memsorb is a CO2 filter replacing current chemical CO2 absorbers
|
Control Group - InspDes
Inspired concentration of desflurane in the control surgical group.
|
Control Group - ExpDes
Expired concentration of desflurane in the control surgical group.
|
|---|---|---|---|---|---|---|---|---|
|
End-tidal CO2 Concentration (%)
|
—
|
—
|
—
|
—
|
5.069 % end-tidal CO2
Standard Deviation 0.8068
|
5.096 % end-tidal CO2
Standard Deviation 0.5995
|
—
|
—
|
OTHER_PRE_SPECIFIED outcome
Timeframe: From the start to the end of the intra-operative period for each participantInhaled and exhaled fraction of anaesthetic agent as collected from the anaesthetic patient record database. Mean % inhalational anesthetic was calculated per surgical procedure. Those means were used to calculate the overall mean
Outcome measures
| Measure |
Memsorb Group - ExpDes
n=42 Participants
Expired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - ExpSEVO
n=81 Participants
Inspired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - inspDes
n=42 Participants
Inspired concentration of desflurane in the memsorb surgical group.
|
Memsorb Group - inspSEVO
n=93 Participants
Inspired concentration of sevoflurane in the memsorb surgical group.
|
Control
n=70 Participants
Patients receive standard care with a standard CO2 absorber and agree to include their data in the study.
|
Memsorb
n=61 Participants
Patients agree to receive standard care but using memsorb, the new CO2 filter evaluated in this study.
memsorb: memsorb is a CO2 filter replacing current chemical CO2 absorbers
|
Control Group - InspDes
n=23 Participants
Inspired concentration of desflurane in the control surgical group.
|
Control Group - ExpDes
n=23 Participants
Expired concentration of desflurane in the control surgical group.
|
|---|---|---|---|---|---|---|---|---|
|
Fraction of Anaesthetic Agent (%)
|
5.158 percentage of fractional anesthetic agen
Standard Deviation 1.536
|
1.732 percentage of fractional anesthetic agen
Standard Deviation 0.5704
|
5.929 percentage of fractional anesthetic agen
Standard Deviation 1.539
|
2.254 percentage of fractional anesthetic agen
Standard Deviation 0.6204
|
2.119 percentage of fractional anesthetic agen
Standard Deviation 0.7444
|
1.603 percentage of fractional anesthetic agen
Standard Deviation 0.6398
|
6.535 percentage of fractional anesthetic agen
Standard Deviation 1.582
|
5.505 percentage of fractional anesthetic agen
Standard Deviation 1.448
|
Adverse Events
Control
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Memsorb
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place
Restriction type: LTE60