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Cerebral Oximetry in Lower Body Negative Pressure

NCT03009305 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-03-17

No results posted yet for this study

Summary

The study aims to describe hemodynamic effects of lower body negative pressure (LBNP).

1. If and how changes in cerebral oxygen saturation (StO2) measured by near infrared spectroscopy (NIRS) relate to changes in blood flow in the carotid arteries during progressive LBNP.
2. If and how mean systemic filling pressure (MSFP) can be measured by brief occlusion of blood flow to an arm and if this relates to LBNP-level.
3. If and how pulse pressure variations and photoplethysmographic amplitude variations during positive expiratory pressure (PEP) and continuous positive airway pressure (CPAP) relate to LBNP-level.

Conditions

  • Hypovolemia

Interventions

OTHER

Lower body negative pressure

Model of hypovolemia: Lower body negative pressure down to -80 mmHg (maximum).

DEVICE

Continuous positive airway pressure

CPAP of 0, 5 and 10 cm water (H2O).

DEVICE

Positive expiratory pressure

PEP of 0, 5 and 10 cm H2O.

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Svein Aslak Landsverk, M.D., PhD · Oslo University Hospital

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2017-03-31
Completion
2017-03-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03009305 on ClinicalTrials.gov