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Image Based Brachytherapy in Locally Advanced Cervical Cancers - a Randomized Controlled Trial

NCT03005743 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1050

Last updated 2026-02-23

No results posted yet for this study

Summary

Purpose of the study is to determine whether Image based brachytherapy is superior in terms of local control to Conventional radiograph based brachytherapy in locally advanced cervical cancers in a Phase III randomized setting.

Conditions

Interventions

RADIATION

Magnetic Resonance Image based Brachytherapy

MRI based BT prescription will be in accordance to the GEC-ESTRO guidelines \[Intention will be to treat the whole cervix and the remaining residual tumour tissue at the primary site at the time of BT (high risk-clinical target volume) to a dose level analogue to the dose level previously prescribed for point-A\]

RADIATION

Conventional Radiograph based Brachytherapy

The standard conventional radiography based prescription will be according to Manchester system Point A and bladder \& rectum ICRU point dose constraints

Sponsors & Collaborators

  • Tata Memorial Hospital

    lead OTHER_GOV

Principal Investigators

  • Supriya Sastri (Chopra), MD · Professor, Department of Radiation Oncology, Tata memorial Hospital, Mumbai 400012

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2025-05-28
Completion
2025-05-28

Countries

  • India

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03005743 on ClinicalTrials.gov