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Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects

NCT02999282 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2020-03-03

No results posted yet for this study

Summary

In this randomized, double-blind, sham-controlled study, the investigators will evaluate the effects of frontal and prefrontal anodal transcranial direct current stimulation (tDCS) on neurophysiological parameters of cortical connectivity, assessed by transcranial magnetic stimulation (TMS), in asymptomatic subjects bearing a pathogenic GRN mutation and in symptomatic patients with frontotemporal dementia.

Conditions

  • Frontotemporal Dementia
  • GRN Related Frontotemporal Dementia

Interventions

DEVICE

Anodal transcranial direct current stimulation

10 sessions of anodal transcranial direct current stimulation (5 days/week for 2 weeks)

DEVICE

Sham transcranial direct current stimulation

10 sessions of sham transcranial direct current stimulation (5 days/week for 2 weeks)

Sponsors & Collaborators

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    lead OTHER

Principal Investigators

  • Barbara Borroni, MD · Azienda Ospedaliera Spedali Civili, Brescia

  • Alberto Benussi, MD · Università degli Studi di Brescia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-10-31
Primary Completion
2019-06-30
Completion
2019-06-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02999282 on ClinicalTrials.gov